During aging, cells display a senescence-associated secretory phenotype (SASP) that transforms normal physiology into pathophysiology of a tissue/organ, leading to its dysfunction. Similarly, the accumulation of
Cellular senescenceis defined as the irreversible exit from the cell cycle. First described as the limited proliferation capacity in long-term cultures of normalsomatic cellswith potential implications in aging, this phenomenon is may be classified as a commoncellular response to stress. Accumulated fin...
Cellular senescence is a process that is mainly designed to eliminate unwanted cells by inducing tissue remodelling. In general, cellular senescence promotes tissue remodelling through three sequential processes: a stable proliferative arrest; a secretory phenotype (SASP) that recruits immune cells and mod...
types including primary fibroblasts and epithelial senescence, are mainly motivated by the important roles played cells, and under conditions that lead to replicative senescence by cellular senescence in both normal physiology and diverse or premature senescence induced by activated Ras oncogene,22 ...
Senescencep21Waf1/Cip1/Sdi1Lac-repressorIPTGHT1080-p21-9Cellular senescence is a unique process of normal physiology, from embryonic development to aging, also known for its association with a broad range of pathological conditions. Therefore a reliable......
Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases. One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can ari
Ionizing radiation-induced cellular senescence in normal, non-transformed cells and the involved DNA damage response: A mini review. Front Pharmacol. 2018;9:522. 121. Shao L, Wang Y, Chang J, Luo Y, Meng A, Zhou D. Hematopoietic stem cell senescence and cancer therapy-induced long-term ...
We begin by describing the most important molecular mechanisms underlying cellular senescence. Then, we focus on the most recent findings that implicate senescence both in normal physiology and in a remarkably wide range of pathological disorders. This is followed by the proposal of a unified model ...
The senescence programme is implicated in diverse biological processes, including embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Althoughin vivostudies of senescence are in their infancy, evidence suggesting that senescent cells are a heterogeneous cell type is accumulating: senesce...
Telomerase, the enzyme that maintains telomere length, is not expressed by most normal somatic (non-stem) cells but is expressed by most cancer cells that have overcome senescence. Moreover, telomerase activity reconstitution in normal cells leads to telomere elongation, extending their replicative ...