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However, mounting evidence suggests that senescent cells, which also persist in vivo, can promote the incidence of aging‐related disorders principally via the senescence‐associated secretory phenotype (SASP), among which cancer is particularly devastating. Despite the beneficial effects of the SASP on...
Mfn1silencing in melanoma cells affects the senescence associated secretory phenotype (SASP). B16-F1 cells were transduced with lentiviral particles carrying shScr or shMfn1 and selected with puromycin. (a)Mfn1expression was determined by RT-qPCR and reported relative to control value. Unpaired t-test...
Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging and age-related disease, and SASP-related inflammation is thought to contribute to tissue dysfunction in aging and diseased animals. However, whether and how SASP factors influence the regenerative capacit...
SASP: Senescence-Associated Secretory Phenotype SD: Standard Deviation SEM: Standard Error of Mean TCGA: The Cancer Genome Atlas TGF-β: Transforming Growth Factor Beta UMAP: Uniform Manifold Approximation and Projection UM: Uveal Melanoma VWF: Von Willebrand Factor ...
Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorably promote tumor progression through paracrine secretion of the senescence-associated secretory phenotype (SASP). Extracellular vesic
suppressing mechanism when induced within premalignant or malignant tumor cells, senescent cells can promote cancer development through increased secretion of growth factors, cytokines, chemokines, extracellular matrix, and degradative enzymes, collectively known as senescence-associated secretory phenotype (SASP...
Senescent-like neutrophils then exert a protumoral function in the TME through their senescence-associated secretory phenotype (SASP). Tumor-derived reprogramming of neutrophils also results in SiglecF+ and T3 neutrophils. These cells, as well as senescent-like neutrophils, are long-lived neutrophil ...
Cellular senescenceis a stress response that imposes a growth arrest on cancer and nonmalignant cells during cancer therapy. By secreting a plethora of proinflammatory factors collectively termed the senescence-associated secretory phenotype (SASP), therapy-induced senescent cells can promote tumorigenesis....
Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, have been reported to increase the malignant potency of cancer cells by secreting senescence-associated secretory phenotype (SASP). Otherwise, Senescence of tumor cells has been believed to inhibit tumor growth by halting ...