Poter AG,Janicke RU.Emerging roles of caspase-3 in apoptosis.Cell Death and Differentiation. 1999Porter AG,Janicke RU.Emerging roles of caspase-3 in apoptosis. Cell Death and Differentiation . 1999Porter AG and Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6...
Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and caspase-11 have roles in inflammation and mediating inflammatory cell death by pyroptosis. Similarly, caspase-8 has dual role in cell de...
Transfer RNAs (tRNAs) play an essential role in mRNA translation by delivering amino acids to growing polypeptide chains. Recent data demonstrate that tRNAs can be cleaved by ribonucleases, and the resultant cleavage products, tRNA-derived small RNAs (ts
Herein, we summarize the roles of RNA sensors in cancer immunity, especially their expression and interaction with immune cells in tumor microenvironment (TME), and describe the insights and emerging cancer immunotherapy strategies based on RNA sensors....
Abstract 5150: JMJD3 suppresses progression of colorectal carcinoma by regulating cell cycle and anti-apoptosis Background: JMJD3 has been known to play important roles in transcriptional regulation and cell proliferation by demethylating histone3 lysin27 (H3K27) in various cancers. However, the mec...
The discovery of lactylation further revealed the role of lactate in regulating inflammatory processes. In this review, we comprehensively summarize the paradoxical characteristics of lactate metabolism in the inflammatory microenvironment and highlight the pivotal roles of lactate homeostasis, the lactate ...
the intracellular domain of the CD3ε subunit of T cell receptor can undergo LLPS with Lck, which facilitates rapid T cell activation [11]. There may also be unreported LLPS droplets involved in the interaction between NK cells and their ligands during the apoptosis and ADCC of target cells....
Table 1 Therapeutic roles of colchicine and IL-1 inhibitors in T2DM Full size table The anti-inflammatory properties of glucose-lowering drugs In addition to IL-1 antagonists and colchicine, several glucose-lowering drugs used in clinical practice exhibit significant anti-inflammatory properties, includi...
pathways related to ferroptosis have been reported, including the tetrahydrobiopterin (BH4)/coenzyme Q10 (CoQ10) system and the dihydroorotate dehydrogenase (DHODH)/CoQ10axis [20]. In the subsequent sections of this review article, we discuss the roles of these metabolic pathways in ferroptosis (...
Exosomes in the progression of oral diseases As researchers have demonstrated the intricate roles of exosomes in biological events, their distinct alterations are significant components in the pathological processes of oral diseases. At the initial stage, analyzing the exosomal information helps to improve...