Although the funda- mental roles of caspases in the mammalian apoptotic machinery have been elucidated, it is not known which caspase or caspases play a major role in Fas-mediated apoptosis of β-cells. In this study, we transfected human Fas cDNA into a mouse β-cell line (βTC1) and ...
According to the effect on metamorphosis, the function of caspases in larvae was analyzed. The results reveal that the main apoptosis event occurred in the velum of pediveliger before metamorphosis, indicating that the degradation of velum might be the process of apoptosis. The activated caspases ...
Caspases are a large family of evolutionarily conserved, aspartate-specific cysteine proteases that are essential for the initiation and execution of apoptosis1-3. Mammalian caspases can be subdivided into three functional groups: initiator caspases (caspase 2, 8, 9, and 10), executio...
Apoptosis, a form of programmed cell death that occurs under physiological as well as pathological conditions, is characterized by morphological and biochemical features. While the importance of caspases in apoptosis is established, several noncaspase proteases (Ca2+-dependent proteases) such as calpain ...
Caspases are critical mediators of apoptosis and proliferation of peripheral blood T cells (PBT), but their role in lamina propria T cells (LPT), a cell population highly susceptible to apoptosis, has not been explored. RA+, RO+ PBT, and LPT were activated with CD3, CD2, and CD28 antibodi...
Role of Caspases, Bax and Bcl-2 in Chrysin-Induced Apoptosis in the A549 Human Lung Adenocarcinoma Epithelial Cells[J] . Saeed Samarghandian,Mohsen Azimi Nezhad,Gholamreza Mohammadi.Anti-Cancer Agents in Medicinal Chemistry . 2014 (6)Samarghandian S, Nezhad MA, Mohammadi G. Role of caspases...
1. SAID TM, Grunewald S, Paasch U, Sharma RK, Glander H-J, Agarwal A (2004): Assessment of spermatozoal caspases in oxidative stress mediated apoptosis. In: 60th Annual Meeting of the American Society for Reproductive Medicine, October 1... TM Said,Kattal,RK Sharma,... 被引量: 0发表...
所导致.Mst3所导致的细胞凋亡不会被广效性casapase抑制剂 (zVAN-fmk) 所抑制,而且Mst3和caspase-3共同表现也不会促进细胞凋亡之现象.Mst3引起细胞凋亡的分子机转仍有待研究.Mst 3 (Mammalian Ste20-like protein kinase 3), a 52 kDa protein, plays an important role in the process of cell apoptosis....
Background: Apoptosis is a necessary process to control cell numbers in multicellular organisms. In many chronic inflammatory diseases, reduced cell death of different types of granulocytes is one important mechanism for cell accumulation. Here, we studied the role of caspases in neutrophil and eosinop...
Here, we investigate key effectors of cell death, caspases, in human neuronal apoptosis and APP processing. We find that caspase-6 is activated and responsible for neuronal apoptosis by serum deprivation. Caspase-6 activity precedes the time of commitment to neuronal apoptosis by 10 h, indicating...