In contrast, caspase-7 has no significant role in sensitivity to intrinsic cell death, but it is responsible for ROS production and cell detachment. Taken together, these data suggest that caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis....
Caspase-3 and -7 are generally known for their central role in the execution of apoptosis. However, their function is not limited to apoptosis and under specific conditions activation has been linked to proliferation or differentiation of specialised cell types. In the present study, we followed ...
www.nature.com/cddis Non-apoptotic functions of caspase-7 during osteogenesis E Svandova1,2, H Lesot3,4, T Vanden Berghe5,6, AS Tucker7, PT Sharpe7, P Vandenabeele5,6 and E Matalova*,1,2 Caspase-3 and -7 are generally known for their central role in the execution of apoptosis...
Thus, caspase-7 may play a role in the glial and inflammatory responses, and possibly neuronal death, after TBI in humans. 展开 关键词: apoptosis cysteine protease head injury inflammation programmed cell death DOI: 10.1089/neu.2006.23.1583 被引量: 25 ...
Apoptosis plays an important role in larval development of species. Taking clam Meretrix meretrix as an example, to the apoptosis and function of caspase in bivalve larvae development and metamorphosis were studied. Apoptosis was detected in larvae at different stages with TUNEL labeling (Terminal-...
5. Newton, K. et al. Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.Nature574, 428–431 (2019). 6. Henry, C. M. & Martin, S. J. Caspase-8 acts in a non-enzymatic role as a scaffold for assembly of a pro-inflammatory “FADDosome” complex upon...
背景资料This Caspase-7 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to...
Caspases are proteases at the heart of networks that govern apoptosis and inflammation. The past decade has seen huge leaps in understanding the biology and chemistry of the caspases, largely through the development of synthetic substrates and inhibitors. Such agents are used to define the role of...
(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to ...
Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms[J]. Hum Genet, 1995, 95(6):641-644. [13]TERRY MR, ARYA R, MUKHOPADHYAY A, et al. Caspase-2 impacts...