Caspase 3 is involved in the apoptosis induced by triptolide in HK-2 cells[J] . Bin Shu,Weigang Duan,Jincheng Yao,Jingfeng Huang,Zhenzhou Jiang,Luyong Zhang.Toxicology in Vitro . 2009 (4)Shu B, Duan W, Yao J, et al. Caspase 3 is involved in the apoptosis induced by triptolide in ...
and factors released from cytotoxic T cells. The caspases comprise a class of cysteine proteases many members of which are involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade,
Group I activity increased also, but the basal level in non-serum-deprived neurons was already high, suggesting that it may not be significantly involved in apoptosis. In addition, group I activity was very low at 12 h of serum deprivation, the time of Aβ measurement in serum-deprived ...
There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then...
CONCLUSION: Apoptosis and caspase-3 are not only involved in the long-term renal I/R injury, but also mediate the divergent effects of immunosuppression in this model. 展开 关键词: apoptosis caspase-3 immunosuppressants ischemia/reperfusion injury ...
In regards to autophagy, the modulatory roles of caspases have only recently begun to be adequately described. In contrast to apoptosis, autophagy promotes cell survival by providing energy and nutrients through the lysosomal degradation of cytoplasmic constituents. Under basal conditions autophagy and ...
Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms[J]. Hum Genet, 1995, 95(6):641-644. [13]TERRY MR, ARYA R, MUKHOPADHYAY A, et al. Caspase-2 impacts...
Caspase-7: A protease involved in apoptosis and inflammation with caspase-3 because these related cysteine proteases share an optimal peptide recognition sequence and have several endogenous protein substrates in common. ... M Lamkanfi,TD Kanneganti - 《International Journal of Biochemistry & Cell ...
Caspases are at the core of executing apoptosis by orchestrating cellular destruction with proteolytic cascades. Caspase-mediated proteolysis also controls diverse nonlethal cellular activities such as proliferation, differentiation, cell fate decision,
Caspase-7: a protease involved in apoptosis and inflammation. Int J Biochem Cell Biol 2010; 42: 21–24. 16 Slee EA, Adrain C, Martin SJ. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 2001; 276: 7320–...