Caspase-3 has a nonapoptotic function in erythroid maturation. Blood 2004;103:4310-4316. [PubMed: 14976035]Carlile GW, Smith DH, Wiedmann M (2004) Caspase-3 has a nonapoptotic function in erythroid maturation. Blood 103: 4310-4316.Carlile, G.W., Smith, D.H., and Wiedmann, M. (2004)...
因此,为了确定caspase-3在凋亡对这些免疫信号影响中的作用,作者用siRNA敲除293 T细胞中的caspase-3,结果显示,caspase-3敲除后,凋亡介导的对IL-1β诱导的CXCL10、IKBA或MCP-1转录的抑制被明显抵消了(图2A)。然后,作者通过CRISPR-Cas9在293T-TLR3细胞中进行了caspase-3敲除(KO)。结果显示,caspase-3的缺失明显增强...
role in celFs life activities.A p o ptosis is mainly regulated b y the Caspase protease family,in w h i c h Caspase-3plays a crucial role.In this review,the composition a n d function of the Caspase family,the characteristics a n d m e c h a n i s m of Caspase-3 are...
Caspase-3 siRNA Caspase-3 (CASP3) is the main effector enzyme in the process ofapoptosisand inflammation, and it has been widely concerned as the therapeutic target ofAKI. It is reported that siRNA targetingCaspase-3can effectively silence CASP3, inhibit the expression ofHMGB1and IL-1β, reduce...
The cross-linking of Fas by anti-Fas resulted in the elevation of caspase-3-like, but not caspase-1-like, protease activity 2-12 h after the addition of the anti-Fas. A caspase-3 inhibitor, Z-Asp-Glu-Val-Asp-fluoromethyl ketone, attenuated the Fas-mediated beta-cell apoptosis, while ...
In addition, all changes detected were positively correlated with renal structure and function. CONCLUSION: Apoptosis and caspase-3 are not only involved in the long-term renal I/R injury, but also mediate the divergent effects of immunosuppression in this model. 展开 关键词: apoptosis caspase-3...
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF-R. Int J Mol Med, 2018, 41(6): 3243-3252. 18. Pandey P, Sayyed U, Tiwari RK, et al. Hesperidin induces ROS-mediated apoptosis along with cell cycle arrest at...
but when DFNA5 is stably expressed in these cells they progress to secondary necrosis. These findings indicate that DFNA5 regulates progression of apoptotic cells to secondary necrosis and may also function to prevent cellular disassembly into small apoptotic bodies during apoptosis. Since progression to...
CASPASE3凋亡抑制剂抗体是用CASPASE3凋亡抑制剂对无菌动物进行系统免疫后在其体内产生的一种抗体蛋白。细胞凋亡是机体内细胞死亡的重要途径,目前发现真核细胞主要经死亡受体介导的外部凋亡途径、内部线粒体途径、B粒酶介导的细胞凋亡途径及近几年开始关注的内质网应激途径介导细胞发生凋亡。主要有4种蛋白分子家族参与细胞凋...
Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway. Caspase-3 cleavage and activation are known to play central roles in apoptosis. However, the mechanisms that regulate caspase-3 cleavage remain elusive. Gl....