Apoptosis is a non-inflammatory form of programmed cell death (PCD) mediated by activation of the apoptotic caspases and can occur either via an intrinsic or an extrinsic pathway4. The intrinsic pathway is activated by mitochondrial damage. Subsequently the cytochrome c release into the cytoplasm fr...
[3]Resveratrol,a tumor-suppressive compound from grapes induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.Tinhofer I,Bernhard D,Senfter M,et al.The FASEB Journal.2001 [4]Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 act...
This pathway bypasses the need for activated caspase 3 in these cells. Oncogene (2001) 20, 6570鈥 6578.LiangYeYanChaohuaSchorNinaFEBSCO_AspOncogeneLiang Y, Yan C, and Schor NF (2001). Apoptosis in the absence of caspase-3. Oncogene 20, 6570 - 6578....
Mol Cell. 1998Jun;1(7):949-57.PubMed ID: 9651578 2. Pirnia F,Schneider E, Betticher DC, Borner MM.Mitomycin C induces apoptosis andcaspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.CellDeath Differ. 2002 Sep;9(9):9...
科研的成功之路（pathway）上绕不过去的 靶点—caspase！订阅号APExBIO 5月1，Nature在线刊登了北京生命科学研究所（NIBS）邵峰院士组的一篇名为“Chemotherapy drugs induce pyro ptosis through caspase-3 cleavage of a Gasdermin”的研究性论文，该研究揭示了化疗药物诱导的细胞焦亡是通过活化的caspase-3对Gasdermin E...
【12】Jiang M, et al. The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer. Cell Death Discov. 2020 Oct 28;6:112. 【13】Sheng M, et al. Caspase-6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver...
2. Pirnia F,Schneider E, Betticher DC, Borner MM.Mitomycin C induces apoptosis andcaspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.CellDeath Differ. 2002 Sep;9(9):905-14.PubMed ID: 12181741 3. Swanton E,Savory P, Cosulich S, Clarke P, Woodman P.Bcl-2 re...
higherefficientcombinationaltherapies.Inthisproject,fluorescenceresonanceenergytransfer(FRET)probeCD3,whichiscomposedofanenhancedcyanfluorescentprotein(CFP),aCaspase-sensitivelinker,andaredfluorescentproteinfromDiscosoma(DsRed),wasusedtodetecttheactivationofCaspase-3inthesignalpathwayoftumorcellapoptosisviaHSV-TK/GCVand...
Fig. 2. Lnc-HZ01 induced humantrophoblast cell apoptosis by activating p53/caspase-3 pathway. 通过用p53过表达质粒转染细胞或用其特异性激活剂Nutlin-3处理细胞来上调p53,增加了Swan 71和HTR-8/SVneo细胞中p53、caspase-3和cleaved caspase-3的表达水平(图2a)。相反,通过用不同的siRNA转染细胞或用其特异性...
Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation. Both apoptosis and pyroptosis are caspase-dependent programmed cell death pathways. Cysteinyl as...