Apoptosis is a non-inflammatory form of programmed cell death (PCD) mediated by activation of the apoptotic caspases and can occur either via an intrinsic or an extrinsic pathway4. The intrinsic pathway is activated by mitochondrial damage. Subsequently the cytochrome c release into the cytoplasm fr...
This pathway bypasses the need for activated caspase 3 in these cells. Oncogene (2001) 20, 6570鈥 6578.LiangYeYanChaohuaSchorNinaFEBSCO_AspOncogeneLiang Y, Yan C, Schor NF (2001). Apoptosis in the absence of caspase-3. Oncogene, 20, 6570-8....
[3]Resveratrol,a tumor-suppressive compound from grapes induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.Tinhofer I,Bernhard D,Senfter M,et al.The FASEB Journal.2001 [4]Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 act...
Mol Cell. 1998Jun;1(7):949-57.PubMed ID: 9651578 2. Pirnia F,Schneider E, Betticher DC, Borner MM.Mitomycin C induces apoptosis andcaspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.CellDeath Differ. 2002 Sep;9(9):9...
Downregulation of microRNA-21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM-1 cells. Mol Med Rep, 2018, 18(3): 2771-2779. 21. Pan H, Li T, Jiang Y, et al. Overexpression of circular RNA ciRS-7 abrogates the tumor suppressive...
2. Pirnia F,Schneider E, Betticher DC, Borner MM.Mitomycin C induces apoptosis andcaspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.CellDeath Differ. 2002 Sep;9(9):905-14.PubMed ID: 12181741 3. Swanton E,Savory P, Cosulich S, Clarke P, Woodman P.Bcl-2 re...
P21 is detected only after activation of caspase 7, and P53 is neither expressed at baseline nor up-regulated with apoptosis induction. This pathway bypasses the need for activated caspase 3 in these cells. 展开 关键词:breast cancer programmed cell death caspases ...
《Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-3β signaling pathway》 作者:Baoquan Li,Xiaoguang Li 期刊:Biomedicine & Pharmacotherapy 影响因子:3.743 PMID:30142548 ...
(Xchromosomelinkedinhibitorofapoptosis) 通过直接 抑制活化的 caspase-3, 而抑制 Fas 诱导的细胞凋亡 OP21 直接 与 caspase-3 前体结合 , 形成 caspase-3 前体 /P21 复合物 , 通 过抑制 caspase-3 的激活而抑制 Fas 诱导的细胞凋亡 O 3.2 Caspase-3 在 TGF- 1 诱导肝癌细胞凋亡中的作用 TGF- 1 是一种...
Apoptosis Induced by TNF or Staurosporine Does Not Correlate with the Activation of Caspase-3 HeLa D98 and H21 carcinoma cells, which are highly or only marginally sensitive to TNF-induced apoptosis, respectively (16), were treated with TNF or staurosporine, and the percentage of apoptosis was ...