YAMADA K,ICHIKAWA F,ISHIYAMA SS,et al.Essential role ofcaspases-3 in apoptosis of mouse beta-cells transfected with humanFas. Diabetes . 1999Yamada K, Ichikawa F, Ishiyama-Shigemoto S, Yuan X, Nonaka K: Essen- tial role of caspase-3 in apoptosis of mouse beta-cells transfected with ...
Based on the confirmation that microcystin-LR (MCLR) could induce apoptosis of renal cells of rat, fluorescent dye labeled specific inhibitor of caspase-3 was adopted in this study to detect the enzyme activity of caspase-3 in live cells and to probe into the role played by caspase-3 in MC...
The cross-linking of Fas by anti-Fas resulted in the elevation of caspase-3-like, but not caspase-1-like, protease activity 2-12 h after the addition of the anti-Fas. A caspase-3 inhibitor, Z-Asp-Glu-Val-Asp-fluoromethyl ketone, attenuated the Fas-mediated beta-cell apoptosis, while ...
The activity of caspase-3 decreased after blocking the activation of caspase-8, while the activity of caspase-8 didn't change after blocking the activation of caspase-3. The inhibitors of caspase-8 and caspase-3 blocked the activation of caspase-8 and caspase-3 and reduced the apoptosis of ...
Caspase发育变态Apoptosis plays an important role in larval development of species. Taking clam Meretrix meretrix as an example, to the apoptosis and function of caspase in bivalve larvae development and metamorphosis were studied. Apoptosis was detected in larvae at different stages with TUNEL labeling...
The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion 6 (2012) 309-316.Didonna A, Sussman J, Benetti F, Legname G. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012; 6 :309–316....
Purpose: Cisplatin (cis-diamminedichloroplatinum(II), CDDP) has been reported to induce apoptosis in cancer cells? the mechanism of the apoptosis in cancer cells induced by CDDP is still unclear. Recent studies have revealed that caspase family of cystine proteases play an important role in the...
Results: Caspases 3 and 8 are critically involved in the regulation of neutrophil apoptosis in vitro. In contrast, these two caspases did not appear to play a major role in the regulation of eosinophil apoptosis. However, the broad-range caspase inhibitor VAD prevented eosinophil death, indicating...
Apoptosis in most cell types is accompanied by altered Ca(2+) homeostasis. During apoptosis, caspase-3 mediated cleavage of the type 1 inositol 1,4,5-trisphosphate receptor (IP3 R1) generates a 95-kDa C-terminal fragment (C-IP3 R1), which represents the channel domain of the receptor. Age...
Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway. Caspase-3 cleavage and activation are known to play central roles in apoptosis. However, the mechanisms that regulate caspase-3 cleavage remain elusive. Gl....