Harvey NL and Kumar S (1998) The role of caspases in apoptosis. Adv. Biochem. Eng. Biotechnol. 62: 107 ± 128Harvey NL,Kumar S.The role of Caspase in apoptosis. Advances in Biochemical Engineering/Biotechnology . 1998Kumar, S., and Cakouros, D. (2003) The role of caspases in ...
Having detected no signal in the velum, we proposed that the apoptosis in velum might be caspase-independent. The 4-day-old and 5-day-old larvae under treatment of caspase inhibitor showed significant lower metamorphosis rates than that in the DMSO control group (P<0.05). The results indicate...
that microcystin-LR (MCLR) could induce apoptosis of renal cells of rat, fluorescent dye labeled specific inhibitor of caspase-3 was adopted in this study to detect the enzyme activity of caspase-3 in live cells and to probe into the role played by caspase-3 in MCLR induced apoptosis. MCLR...
In the central nervous system caspase-2 is highly expressed in the brain during development although many caspases are expressed at low levels in the adult. However, an involvement of caspases in apoptosis of mature neurons has been demonstrated in vivo, where specific inhibitors of caspases are ...
The apoptosis-associated Speck-like protein containing a caspase-1 recruitment domain (ASC), present in inflammasomes, regulates inflammation events and is involved in osteogenic phenotype. Nevertheless, its function in bone repair induced by bone substitute biomaterials is unclear. This study aimed to ...
dependent, aspartate-specific proteases) such as caspase-3 play an important role in mediating cell death in that many of the apoptotic signaling pathways, such as the mitochondrial-mediated, receptor-mediated, and sarcoplasmic-reticulum-mediated pathways, converge at caspase-3 in the caspase cascade...
For example, in some cell types NO can promote apoptosis, whereas in other cells NO inhibits apoptosis. In hepatocytes, NO can inhibit the main mediators of cell death—caspase proteases. Moreover, low physiological concentrations of NO can inhibit apoptosis, but higher concentrations of NO may ...
Conclusions Caspase-8 mediates caspase-3 activation during 5-Fu induced apoptosis of HepG2 cells. Blockade of caspase cascade can inhibit apoptosis of HepG2 cells induced by 5-Fu via caspase cascade pathway. 展开 关键词: Fluorouracil hepatoma cells apoptosis caspase-8 caspase-3 ...
Role of Caspase-3 Cleaved IP3R1 on Ca2+ Homeostasis and Developmental Competence of Mouse Oocytes and Eggs Apoptosis in most cell types is accompanied by altered Ca2+ homeostasis. During apoptosis, caspase-3 mediated cleavage of the type 1 inositol 1,... Nan,Zhang,and,... - 《Journal of ...
AIF is a novel, mammalian, caspase-independent death effector that, upon the induction of apoptosis, translocates from the mitochondrial intermembrane space to the nucleus [15]. Once in the nucleus, AIF causes chromatin condensation and large-scale (~50 kb) DNA fragmentation [8]. AIF-mediated ...