Caspase-4Caspase-5Caspase-6Caspase-7Caspase-8Caspase-9The process of apoptosis, or programmed cell death, is fundamental during normal development and homeostasis and aberrant apoptosis has been implicated in a number of human diseases. The cellular machinery involved in the execution of apoptosis ...
Having detected no signal in the velum, we proposed that the apoptosis in velum might be caspase-independent. The 4-day-old and 5-day-old larvae under treatment of caspase inhibitor showed significant lower metamorphosis rates than that in the DMSO control group (P<0.05). The results indicate...
Apoptosis, a form of programmed cell death that occurs under physiological as well as pathological conditions, is characterized by morphological and biochemical features. While the importance of caspases in apoptosis is established, several noncaspase ...
8, 9, and 10), executioner caspases (caspase 3, 6, and 7), and inflammatory caspases (caspase 1, 4, 5, 11, and 12)3. Initiator caspases initiate the apoptosis signal while the executioner caspases carry out the mass proteolysis that leads to apoptosis. Inflammatory...
that microcystin-LR (MCLR) could induce apoptosis of renal cells of rat, fluorescent dye labeled specific inhibitor of caspase-3 was adopted in this study to detect the enzyme activity of caspase-3 in live cells and to probe into the role played by caspase-3 in MCLR induced apoptosis. MCLR...
In the central nervous system caspase-2 is highly expressed in the brain during development although many caspases are expressed at low levels in the adult. However, an involvement of caspases in apoptosis of mature neurons has been demonstrated in vivo, where specific inhibitors of caspases are ...
Caspase-6 activity precedes the time of commitment to neuronal apoptosis by 10 h, indicating possible activity without subsequent apoptosis. Inhibition of caspase-6 activity prevents serum deprivation-mediated increase of Aβ. Caspase-6 directly cleaves APP at the C terminus and generates a C-...
Caspases (ICE/ Ced3 proteases) are a closely related family of cysteine proteases that play a key role in apoptotic cell death. We examined the role of caspases in DNA damage and cell death in response to the mitochondrial inhibitor, antimycin A. LLC-PK1 cells contain caspase activity that ...
Role of Caspase-3 Cleaved IP3R1 on Ca2+ Homeostasis and Developmental Competence of Mouse Oocytes and Eggs Apoptosis in most cell types is accompanied by altered Ca2+ homeostasis. During apoptosis, caspase-3 mediated cleavage of the type 1 inositol 1,... Nan,Zhang,and,... - 《Journal of ...
The strong induction of caspase-1 (Casp1) prompted us to explore its involvement in the apoptotic process. We therefore generated double knock-out mice deficient for both retinoschisin and Casp1. No direct influence of the Casp1 genotype on apoptosis could be identified although striking ...