Emerging roles of caspase-3 in apoptosis. Cell Death Differ 1999;6:99-104.Poter AG,Janicke RU.Emerging roles of caspase-3 in apoptosis.Cell Death and Differentiation. 1999Porter AG,Janicke RU.Emerging roles of caspase-3 in apoptosis. Cell Death and Differentiation . 1999...
Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and caspase-11 have roles in inflammation and mediating inflammatory cell death by pyroptosis
Transfer RNAs (tRNAs) play an essential role in mRNA translation by delivering amino acids to growing polypeptide chains. Recent data demonstrate that tRNAs can be cleaved by ribonucleases, and the resultant cleavage products, tRNA-derived small RNAs (ts
In non-small-cell lung cancer (NSCLC), the expression of TLR3 on cancer cells contributed to stimulated CD103+ lung dendritic cell subset, activated caspase-3 and induced apoptosis [33]. TAMs are the main component of TME, and known to release tumor necrosis factor-α (TNF-α) in ...
A polymorphism in JMJD2C alters the cleavage by caspase-3 and the prognosis of human breast cancer JMJD2C is a candidate oncogene that encodes a histone lysine demethylase with the ability to demethylate the lysine 9 residue of histone H3 (H3K9). The exp......
The discovery of lactylation further revealed the role of lactate in regulating inflammatory processes. In this review, we comprehensively summarize the paradoxical characteristics of lactate metabolism in the inflammatory microenvironment and highlight the pivotal roles of lactate homeostasis, the lactate ...
Vasculopathy in the setting of cardiorenal syndrome: the roles of protein-bound 2 uremic toxins Am J Physiol Heart Circ Physiol, 313 (2017), pp. H1-H13 Google Scholar 49 K.A. Hruska, T. Sugatani, O. Agapova, et al. The chronic kidney disease-mineral bone disorder (CKD-MBD): advances...
stimulator of interferon genes; TBK1: TANK-binding kinase 1; IKK: inhibitor of kappa B kinase; IRF3: interferon regulatory factor 3; NF-kB: nuclear factor kappa-B; RIG-I: retinoic acid-inducible gene I protein; MAVS: mitochondrial antiviral signaling protein; CARD: caspase activation and recrui...
pathways related to ferroptosis have been reported, including the tetrahydrobiopterin (BH4)/coenzyme Q10 (CoQ10) system and the dihydroorotate dehydrogenase (DHODH)/CoQ10axis [20]. In the subsequent sections of this review article, we discuss the roles of these metabolic pathways in ferroptosis (...
The PI3K/Akt pathway promotes cell growth and proliferation by enhancing protein synthesis and inhibiting apoptosis. Activation of mTORC1 increases protein translation and cell growth [32]. Akt phosphorylates and inactivates pro-apoptotic factors such as BAD and procaspase 9, thereby promoting cell sur...