Apoptosis and Caspase-3, Rate My ScienceMolecular cloning of the interleukin-1 beta converting enzymeCaspasa
【12】Jiang M, et al. The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer. Cell Death Discov. 2020 Oct 28;6:112. 【13】Sheng M, et al. Caspase-6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver....
that microcystin-LR (MCLR) could induce apoptosis of renal cells of rat, fluorescent dye labeled specific inhibitor of caspase-3 was adopted in this study to detect the enzyme activity of caspase-3 in live cells and to probe into the role played by caspase-3 in MCLR induced apoptosis. MCLR...
Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation. Both apoptosis and pyroptosis are caspase-dependent programmed cell death pathways. Cysteinyl as...
SynonymsApopain precursor; CASP-3; CPP-32; CPP32; Caspase-3; Cysteine protease CPP32; EC 3.4.22.-; ICE3; SCA-1; SREBP cleavage activity 1; Yama protein CategoryApoptosis BackgroundCaspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either part...
Caspase3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 1998;273:9357-60.Janicke RU, Sprengart ML, Wati MR, Porter AG. Caspase-3 is required for DNA...
Role of the inflammasome in the pathogenesis and immune responses to Staphylococcus aureus infection in the central nervous system. The NLRP3 inflammasome consists of the NLRP3 protein, the adapter protein ASC (apoptosis-associated speck-like caspase-1 recruiting domain-containing protein... R Hanamsa...
Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis. The mechanism by which this occurs is unknown. Here we show tha...
large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. Caspase-3 is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteo...
Moreover, PHF-1 tau and active caspase-3 were colocalized mostly in tangle-bearing neurons. The current findings suggest that PHF-1 tau is cleaved by caspase-3 during apoptosis and neurodegenerative process in AD. 展开 关键词: Alzheimer's disease Neurofibrillary tangles Caspase-3 Apoptosis Tau ...