The efficacy of mRNA-based vaccines and therapies relies on lipid nanoparticles (LNPs) as carriers to deliver mRNA into cells. The chemical structure of ionizable lipids (ILs) within LNPs is crucial in determining their delivery efficiency. In this study
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable oligomers (IOs) that, with polylactide-polyethylene glycol (PLA-PEG),
15 A variety of nanoparticles constructed from lipids, polymers and metals have already been evaluated as delivery systems for siRNAs,16 and similar conceptual frameworks have been applied to miRNA mimics and anti-miRNAs.17, 18 Carbon nanotubes (CNTs) have recently gained high popularity as ...
Fluorination is also reported to enhance NP stability both in water and phospholipid phase [17], while improving intracellular delivery and endosomal escape [19–21]. In fluorine chemistry, the use of short and branched rather than linear fluorinated ligands has been reported to be advantageous in...
The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People's Republic of China Tel/fax +86 21 81870801 Email yjguo@smmu.edu.cn; liwei.dds@gmail.com Abstract: The main obstacles for cationic polyplexes in gene delivery are in vivo instability and low solid-tumor accumul...
5. Nanocarriers for effective therapeutic delivery 6. Overview on systemic and localized drug delivery 7. Targeting cervical cancer through nanocarriers (NCs) 8. Lipid-based nanocarriers 9. Phyto-nanomedicines against cervical cancer 10. A brief overview of photothermal/radiation/gene therapy 11. Challe...
vera does not develop a central tap root, but produces a highly branched root system with many fine roots that permit the tree to efficiently absorb water and nutrients from the soil. Leaves are pinnately-compound with broad, elliptical to round-ovate leaflets. Each leaf covers a single ...
The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles. Pharmaceutics 2020, 12, 1068. [Google Scholar] [CrossRef] [PubMed] Medina-O’Donnell, M.; Rivas, F.; Reyes-Zurita, F.J.; Martinez, A.; Lupiañez, J.A.; ...
we have demonstrated that the osteoblastic phenotypic shift of cultured VIC is impeded by Runx2 silencing using fullerene (C60)-polyethyleneimine (PEI)/short hairpin (sh)RNA-Runx2 (shRunx2) polyplexes. Since the use of polyplexes for in vivo delivery is limited by their instability in the plas...
Introduction In recent decades there has been significant interest in the preparation of new materials for the delivery of drugs and imaging agents. This interest is motivated mainly by the problematic properties of these molecules. For example, while genomics and proteomics are revealing many ...