agent.Lipid carriers are distinguishable and promising vehicles for mRNA delivery,owning the capacity to encapsulate and deliver negatively charged drugs to the targeted tissues and release cargoes at the desired time.Here,we first summarized the structure and properties of different lipid carriers,such ...
Rising trends are identif i ed, such as nanostructured lipidcarriers and solid lipid nanoparticles becoming the preferred platforms for numerous formulations. Recent advancements inLNP formulations as drug delivery platforms, such as antitumor and nucleic acid therapeutics and vaccine delivery systems, are...
Furthermore, while cationic lipids have high efficiency in vitro, a separate class of lipids termed ionizable cationic lipids have improved pharmacokinetics and are used for in vivo delivery11,18. Here we tested which classes of transfection agents can deliver mRNA to platelets. We found that ...
Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and toxi
These LNP micelles serve as protective carriers for the mRNA, shielding it from degradation by enzymes in the bloodstream. First the drug, mRNA vaccines for example, is encapsulated within LNPs. For RNA interference (RNAi) drugs, such as small interfering RNA (siRNA) or short hairpin RNA (sh...
Intratumoral injection of LNP-formulated mRNA leads to efficient protein expression in myeloid and cancer cells Lipid-based nanoparticles are highly effective carriers to enhance mRNA delivery in vivo. The ionizable lipid is considered the most critical component within the LNP, as it mediates mRNA en...
Liposomes, an early version of LNPs, are a versatile nanomedicine delivery platform. A number of liposomal drugs have been approved and applied to medical practice. Subsequent generations of lipid nanocarriers, such as solid lipid nanoparticles, nanostructured lipid carriers, and cationic lipid–nucleic...
Messenger RNA (mRNA) Similar to DNA, mRNA can also achieve different modes of gene modulation. Some examples include: therapeutic protein overexpression by encoding the protein of interest, or gene knockout by encoding for CRISPR/Cas9. In non-viral gene delivery, a major advantage of mRNA compar...
The size of nanocarriers has a great influence on the drug loading efficacy and the delivery mechanism during ocular drug delivery. To ensure effective medication delivery, drug carriers must be small enough to penetrate the ocular barriers, while also being well-tolerated by the human eye [67]....
Therefore, siRNA might be used ubiquitously for the treatment of a broad spectrum of diseases caused by the overexpression of one or multiple genes 展开 关键词: colloidal carriers drug delivery lipid-based delivery systems liposomes nanomedicine RNA interference siRNA targeting 年份: 2012 ...