Resistance to drugs targeting protein synthesis in mycobacteria. Trends Microbiol. 1994; 2 :416–421.Böttger EC (1994) Resistance to drugs targeting protein synthesis in mycobacteria. Trends Microbiol 2: 416–421Böttger, E. C. 1994. Resistance to drugs targeting protein synthesis in ...
A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds Article Open access 21 October 2024 Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker Article 18 May 2020 Machine learning reveals that st...
These simple changes were designed to obtain a preliminary assessment of the extent to which the scaffold could be perturbed, which would be useful in the eventual design of probe molecules to identify the protein target of nitrofen, but we also imagined that some of these compounds might ...
Drugs that target the neuronal sodium channel by stabilizing the inactive state have long been known to limit the development of seizure activity [15]. The main AEDs operating through this mechanism include phenytoin and its prodrug phospenytoin, valproate, divalproex (a 1:1 mixture of valproic ...
In addition to the selective kallikrein inhibitors, there are four broad-spectrum protease inhibitors that inhibit a number of serine proteases, including PKa. Since PKa activates FXII, its inhibition is also a potential target for influencing hemostasis in various diseases. ...
Inhibits protein synthesis in susceptible bacteria by irreversibly binding to 30S ribosomal subunits. In vitro spectrum of activity includes many gram-negative aerobic bacteria (including most Enterobacteriaceae and Pseudomonas aeruginosa) and some aerobic gram-positive bacteria. Inactive against fungi, viruses...
In addition, FUTP can be incorporated into RNA in place of uridine triphosphate (UTP), producing a fraudulent RNA and interfering with RNA processing and protein synthesis. Active in xenograft tumors that are resistant to fluorouracil indicating incomplete cross-resistance between the drugs. Advice...
This review starts with a brief overview on protein synthesis as an anticancer target that is followed by an introduction to translational control in cancer cells and the importance of this process for cancer therapy. Metal-based chemotherapeutic agents are classified according to the transition metal...
hsa-let-7e-5p18 and hsa-mir-98-5p19 target transmembrane protease, serine 2 (TMPRSS2). Other miRNAs have been reported to inhibit viral replication and protein synthesis. Additionally, hsa-miR-323a-5p and hsa-mir-20b-5p were predicted to have an antiviral effect by reducing inflammatory ...
When cells were treated with iron and PVD, the fluorescence of calcein-AM was quenched, indicating that the iron was transported inside the cell and the calcein-AM was able be quenched by iron inside this bacterium. While the bacteria were treated with a combination of bismuth, iron, and ...