6 Candidate targets for the viral NSP5 protease. a, Wild-type NSP5 and NSP5(C145A) (catalytic dead mutant) interactome. b, Domain maps of HDAC2 and TRMT1, illustrating predicted cleavage sites (using NetCorona 1.0). HDAC, histone deacetylase domain; NLS, nuclear localization sequence; MTS...
G protein-coupled signaling systems are the most important targets for therapeutic drugs, most of which are ligands for heptahelical receptors (7TM-R). A single receptor can activate various signaling pathways in different cells; consequently, drugs that target the receptor binding site are not ...
Whereas cyclo-oxygenases (COX1 and COX2) are the established targets for aspirin, it has been reported recently that salicylate (although not aspirin) is a direct activator of AMPK at concentrations that are reached in human plasma after oral treatment with high-dose aspirin (Hawley et al., ...
This Opinion focuses on the potential of GPCRs as targets for the discovery of new drugs to successfully treat T2D.This is a preview of subscription content, access via your institution Access optionsSubscription info for Chinese customers We have a dedicated website for our Chinese customers. ...
Biophysical characterization shows that the binders, which are all smaller than 65 amino acids, are hyperstable and, following experimental optimization, bind their targets with nanomolar to picomolar affinities. We succeeded in solving crystal structures of five of the binder–target complexes, and ...
DMIs have therefore been an attractive group of new drug targets, because their fine modulation would allow for numerous desirable therapeutic effects [3,6,23–26]. However, despite the enormous interest in targeting protein-protein interactions, developing such drugs has proven to be very challengin...
development of conventional targets has been exhausted, the development of drugs targeting difficult targets has attracted much attention. TPD technology uses the natural degradation system in cells to directly degrade proteins, which is expected to fill the gap in solving the problem of patent drugs....
are understood to inhibit one of the parasite's two known calcium transporters, so these transporters are already thought of as viable targets for drug treatments. The other calcium transporter is a type called CAX, so the researchers set out to investigate its role in the parasite's ...
We propose a new method for virtual screening based on protein interaction profile similarity to discover new targets for molecules, including existing drugs. We calculated Target Interaction Profile Fingerprints (TIPFs) based on ChEMBL database to evaluate drug similarity and generated new putative ...
A growing interest in developing orally active protein-kinase inhibitors has recently culminated in the approval of the first of these drugs for clinical use. Protein kinases have now become the second most important group of drug targets, after G-protein-coupled receptors. Here, I give a ...