S.4.02 What are the drug targets in dementia: cognition, behaviour, …?doi:10.1016/S0924-977X(08)70096-8P. RobertEuropean Neuropsychopharmacology
The pathogenesis of SLE is complex, and B cells, T cells, NK cells, dendritic cells, and related cytokines all play important roles in its pathogenesis. Targeted therapies targeting different aspects of SLE pathogenesis have emerged. So what are the current drug targets for the treatment of SLE?
Quality is more important than speed and cost in drug discovery The current analytical way of drug discovery using isolated mechanisms and targets Chemical and biological properties of relevance for drug discovery and the extent to which they are captured in current data Current landscape: is it AI...
Adenosine receptors as drug targets — what are the challenges? Jiang-Fan Chen, Holger K. Eltzschig & Bertil B. Fredholm Nature Reviews Drug Discovery volume 12, pages 265–286 (2013)Cite this article 20k Accesses 37 Altmetric Metrics details Key Points It has been established for several...
Novel therapeutics in areas with a high unmet medical need are based on innovative drug targets. Although ‘biologicals’ have enlarged the space of druggable molecules, the number of appropriate drug targets is still limited. Discovering and assessing the potential therapeutic benefit of a...
Potential drug–drug interactions mediated by ATP-binding cassette (ABC) and solute carrier (SLC) transporters are of clinical and regulatory concern, but the endogenous function of these drug transporters is unclear. Nigam describes the evidence that th
Artificial Intelligence (AI) has the potential to be a powerful tool for tackling some of the world’s most pressing problems. Here are a few key areas where AI could make a significant impact: Climate Change and Sustainability Modeling and Prediction:AI can analyze vast datasets on climate pat...
It targets Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis in patients without other oral antibacterial treatment options.Are quinolones safe for a UTI?The fluoroquinolones, such as ciprofloxacin (Cipro) and levofloxacin (Levaquin, brand name product discontinued) were commonly used for ...
Notably, the anti-plasmodial activity can be significantly improved when 4-aminoquinoline is coupled to the 3-methylene part of the indole-2-one skeleton, indicating that these hybrids (IC50: 0.14-0.42 μM) are potential leads for the development of new antimalarial drugs. In addition, the ...
Here at Teva we are all in for better health and committed to innovative drug development to address the pressing needs of patients. At the forefront of Teva’s innovative medicines pipeline is the development of therapeutic antibodies. Antibodies are complex medicines derived from the immune system...