These principles will be helpful when considering strategies for the screening or design of novel protein synthesis inhibitors that could be developed as new antibiotics. Recent progress in the discovery and development of bacterial protein synthesis inhibitors is illustrated by consideration of the glycyl...
Learn about protein synthesis inhibitors. Explore antibiotics that target protein synthesis, and understand the mechanism of protein synthesis inhibition. Updated: 11/21/2023 Table of Contents Protein Synthesis Inhibitors How Do Antibiotics Affect Protein Synthesis? Antibiotics That Target Prote...
Effects of Antibiotics on Protein Synthesis in Muscle and Implications with regard to the Action of Insulin 来自 国家科技图书文献中心 喜欢 0 阅读量: 29 作者: MANCHESTER,K. L 摘要: MANY compounds are specific inhibitors of protein synthesis and the mechanism of their action has been much ...
Protein synthesishas long been considered as an attractive target in the development of antimicrobial agents, in light of the widespread use of antibacterial antibiotics that target the specific areas of this process. However, application of this idea to the field of antifungal therapy is not an ea...
In this lesson we'll first review the basic steps of building new proteins through protein synthesis. Then we'll look at two main ways that...
Synthesis of an acyl-acyl carrier protein synthetase inhibitor to study fatty acid recyclingFatty acids are essential to most organisms and are made endogenously by the fatty acid synthase (FAS). FAS is an attractive target for antibiotics and many inhibitors are in clinical development. However, ...
Before protein synthesis is started, the ribosome dissociates into two subunits of different size. The protein synthesis is initiated by forming an initiation complex (30S initiation complex) assembling a complex of five species of proteins: small subunit (30S), mRNA molecule, formyl methyonyl-trans...
Many antibiotics, including the macrolides, inhibit protein synthesis by binding to ribosomes. Only some of the macrolides affect the peptidyl transferase ... SM Poulsen,C Kofoed,B Vester - 《Journal of Molecular Biology》 被引量: 321发表: 2000年 In vitro and in vivo evaluation of C-20- an...
Optimizing the production of recombinant proteins is a problem of major industrial and pharmaceutical importance. Secretion of the protein by the host cell considerably simplifies downstream purification processes. However, for many proteins, this is als
Type II fatty acid synthesis (FAS II) is an essential process for bacteria survival, and malonyl-CoA:acyl carrier protein transacylase (MCAT) is a key enzyme in FAS II pathway, which is responsible for transferring the malonyl group from malonyl-CoA to the holo-ACP by forming malonyl-ACP. ...