protein synthesisantibacterialThe resolution of antibiotic鈥搑ibosomal subunit complexes and antibacterial鈥損rotein complexes at the atomic level has provided new insights into modifications of clinically relevant antimicrobials and provided new classes that target the protein cellular apparatus. New chemistry...
& Tor, Y. Antibiotics that target protein synthesis. Wiley Interdiscip. Rev. RNA 2, 209–232 (2011). Article CAS Google Scholar Austad, B. C. et al. Commercial manufacture of Halaven®: Chemoselective transformations en route to structurally complex macrocyclic ketones. Synlett. 24, 333–...
Title: Hybrids of antibiotics inhibiting protein synthesis. Synthesis and biological activity. Authors: Zemlicka J, Fernandez-Moyano MC, Ariatti M, Zurenko GE, Grady JE, Ballesta JP. Abstract: Four hybrid antibiotics combining structural features of chloramphenicol (1a), sparsomycin (2b), lincomycin...
Protein synthesis is an important process in the body especially to the enzymes. Most of the enzymes are made up of protein. Alteration or regulation of the protein synthesis might have an adverse effect on the production of a specific enzyme in the body. Inhibition of protein synthesis is a...
MANY compounds are specific inhibitors of protein synthesis and the mechanism of their action has been much investigated. Not all compounds which inhibit protein synthesis in micro-organisms do so in ribosomal systems of mammalian origin, for example, chloramphenicol 1–3 . In yeasts an interesting ...
Many antibiotics, including the macrolides, inhibit protein synthesis by binding to ribosomes. Only some of the macrolides affect the peptidyl transferase ... SM Poulsen,C Kofoed,B Vester - 《Journal of Molecular Biology》 被引量: 322发表: 2000年 Synthesis and antimicrobial evaluation of 20-deoxo...
DeVries, H, Arendzen, AJ, Kroon, AM (1973) The interference of the macrolide antibiotics with mitochondrial protein synthesis. Biochim Biophys. Acta 331... HD Vries,AJ Arendzen,AM Kroon - 《Biochim Biophys Acta》 被引量: 34发表: 1973年 THE INTERFERENCE OF THE MACROLIDE ANTIBIOTICS WITH TO...
Kroon AM, deJong L (1979) The use of antibiotics to study mitochondrial protein synthesis. Methods Enzymol I VI: 29–39Kroon A. M. and de Jong L. (1979) The use of antibiotics to study mitochondrial protein synthesis, in Methods in Enzymology, (Fleischer S. and Packer L., eds). ...
In this lesson we'll first review the basic steps of building new proteins through protein synthesis. Then we'll look at two main ways that...
Quinolone antibiotics are a class of antibiotics that target bacterial type II topoisomerases, such as DNA gyrase and topoisomerase IV, leading to the inhibition of bacterial DNA synthesis. They are known for their broad-spectrum activity against Gram-negative pathogens and are essential in treating ...