Structure of the bacterial cell wall, the metabolic pathway for the biosynthesis of cell wall, and various antibiotics affecting various stages of cell wall synthesis are presented. Mechanisms of action of the antibiotics and the mechanisms of resistance development to the antibiotics are discussed. ...
The recent development of novel antibacterial agents that target fatty acid synthesis and inhibit cell membrane formation is also discussed.J. WangH.O. SintimReference Module in Biomedical Sciences
WHO offers a new tool and sets a target to accelerate action against antimicrobial resistance The first statement "There is no harm in using the antibiotics that were given previously to a family member or friend for the same purpose."Most of the respondents correctly identified this first statem...
The peptidoglycan cell wall is an essential structure for the growth of most bacteria. However, many are capable of switching into a wall-deficient L-form state in which they are resistant to antibiotics that target cell wall synthesis under osmoprotective conditions, including host environments. L...
For antibiotics that target cell-wall biosynthesis, measurements of cell-wall composition and architecture are crucial to dissecting drug modes of action, and to characterizing changes as bacteria become resistant to an antibiotic. Yet, the Gram-positive cell wall is a heterogeneous insoluble ...
N. et al. Synthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cells. PLoS ONE 10, e0134526 (2015). Article Google Scholar Bozdogan, B. & Appelbaum, P. C. Oxazolidinones: activity, mode of action, and mechanism of ...
McGannon et al found that antibiotics that target DNA synthesis, such as ciprofloxacin (CIP) and TMP/SMZ, showed increased Shiga toxin production, whereas antibiotics that target the cell wall, transcription, or translation did not. [23] Remarkably, high levels of Shiga toxin were detected even...
Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall. FEBS J. 2005;272:2993–3003. CAS PubMed Google Scholar Cisar JS, Ferreras JA, Soni RK, Quadri LEN, Tan DS. Exploiting ...
& Zhu, K. Nonribosomal antibacterial peptides that target multidrug-resistant bacteria. Nat. Prod. Rep. 36, 573–592 (2019). Article CAS PubMed Google Scholar Urakami, T., Tamaoka, J., Suzuki, K.-I. & Komagata, K. Paracoccus alcaliphilus sp. nov., an alkaliphilic and facultatively...
The bacterial cell wall is a key target for antibiotic discovery; it is crucial for cell growth, and provides a physical protective barrier between the cell and its environment. Antibiotics that inhibit bacterial cell wall biosynthesis, such as penicillin and vancomycin, are extremely important in ...