Cell‐Wall‐Targeting Antibiotics Cause Lag‐Phase Bacteria to Form Surface‐Mediated Filaments Promoting the Formation of Biofilms and Aggregatesantibioticsbiofilmsbio-layer interferometrycell adhesionfilamentous bacteriaAntibiotics are known to promote bacterial formation of enhanced biofilms, the mechanism of ...
aureus virulence was identified using human and murine models of infection. Collectively, our data indicate that PrsS and σS function in a similar manner, and perhaps mediate virulence and resistance to DNA damage and cell wall-targeting antibiotics, via a common pathway. 展开 ...
The antibiotics targeting this cell wall are supposed to be unique and less cytotoxic when compared to other antibiotics. To date, antibiotics are still the only choice of treatment to control bacterial infection. Public health expectancy was revolutionized by the introduction of the first antibiotic ...
Cell wall antibiotics are crucial for combatting the emerging wave of resistant bacteria. Yet, our understanding of antibiotic action is limited, as many strains devoid of all resistance determinants display far higher antibiotic tolerance in vivo than s
Antibiotics initiate their action against bacteria by attacking the cell wall. Most antibiotics contain a beta-lactam ring in their structure. It is a... See full answer below.Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our ...
For this purpose, we construct a high-density, randomly-barcoded transposon mutant library and expose it to 19 cell envelope-targeting antibiotics. By quantifying relative mutant fitness with BarSeq, followed by validation with CRISPR-interference, we profile over a hundred functional associations and...
InL. lactis, theoatAgene has been shown to be regulated at the transcriptional level in response to cell envelope stress, which may be provoked by lysozyme or other cell wall-targeting antimicrobials such as bacitracin, vancomycin, and plantaricin [45,47]. It has been proposed that the first ...
This review focuses on target-based approaches for developing new chemical classes of antibacterial agents aimed at the bacterial cell wall. The clinical success of antibiotics such as beta-lactams and glycopeptides validates this chemotherapeutic strategy and emerging resistance to these agents warrants ...
Mycobacteria show a high degree of intrinsic resistance to most antibiotics and chemotherapeutic agents. The low permeability of the mycobacterial cell wall, with its unusual structure, is now known to be a major factor in this resistance. Thus hydrophilic agents cross the cell wall slowly because ...
Multiple antibiotics targeting cell wall were discovered, it is tempting to explore whether these cell wall targeting antibiotics have similar sensitizing effect. Congo red, a dye binding to the lipoproteins pres- ent on the mycobacterial surface46, was used to characterize modifications affecting the ...