However, the molecular pathways that lead to apoptosis are not known. In some cells, apoptosis induced by statins (other inhibitors of protein prenylation) is dependent on protein synthesis. The aim of this study was to further characterize the kinetics and biochemical features of bisphosphonate-...
The protein encoded by PIG-A is essential for the synthesis of the glycosylphosphatidylinositol anchor (GPI anchor). The GPI moiety serves as the membrane anchor for a group of proteins, termed as GPI-anchored proteins. These proteins are functionally diverse and include CD14, Complement inhibition...
protein yields via batch-based eukaryotic systems, a repetitive batch-based synthesis format has been proposed where the microsomes incorporating the MP of interest generated in an initial synthesis reaction can be added to a fresh CF synthesis reaction that has been depleted of its microsomes [19,...
The therapeutic potential ofin vitro-transcribed mRNA (IVT mRNA) extends from prophylactic and therapeutic vaccines to applications such as protein replacement and genome engineering. In this Review, the authors describe the recent developments in the IV
A possible involvement of protein kinases in chlorpromazine and clozapine inhibitory action on CRH activity was also investigated. It was found that wortmannin (0.01 and 0.02 μM), an inhibitor of phosphatidylinositol 3-kinase (PI3-K), significantly attenuated the inhibitory effect of ...
Both artemether and lumefantrine inhibit nucleic acid and protein synthesis. Artemether has rapid onset of action and the drug and its metabolite have elimination half-lives of about 2 hours; lumefantrine has a longer elimination half-life (about 3–6 days). The rationale behind the fixed-combinat...
Amiodarone is a substrate for CYP3A4 and CYP2C8; drugs and other substances that inhibit these isoenzymes may decrease metabolism and increase serum concentrations of amiodarone.Drugs with P-Glycoprotein-Mediated ClearanceAmiodarone inhibits the P-glycoprotein transport system, which may result in unexp...
Although compounds that can inhibit BCSCs have been reported, these compounds are difficult to use as carriers for the widespread delivery of conventional chemotherapeutic drugs. Methods Herein, we synthesize a polymeric nanocarrier, hyaluronic acid-block-poly (curcumin-dithiodipropionic acid) (HA-b-...
that bind to the active region and inhibit this key molecule. Another approach may be to enhance the normal pathway by promoting specific molecules in the normal pathways that may have been affected in the diseased state. In addition, these drugs should also be designed so as not to affect ...
While clinical data regarding the role of glial cells is less clear [25,26], drugs that inhibit glial activation such as pentoxifylline,α-aminoadipate, fluorocitrate, and minocycline have been successful in pre-clinical stage [2,23,24]. Thus, supporting the important role of glial cells for ...