Investigations of the approved drugs with regard to their active agent targets have shown that they mostly bind to proteins and in particular to receptors or enzymes. There is a mechanistic and a structural reason for this. The mechanistic reason is that proteins are the function carriers in the...
Compounds such as verapamil or quinine not only inhibit drug transport by P-glycoprotein but also block the volume-activated Cl− channel purportedly linked to P-glycoprotein expression. More recent studies, CFTR, a channel regulator and coordinator of epithelial secretion Cystic fibrosis, the most ...
M. Protein methyltransferases as a target class for drug discovery. Nat. Rev. Drug Discov. 8, 724–732 (2009). Article CAS PubMed Google Scholar Ribich, S., Harvey, D. & Copeland, R. A. Drug discovery and chemical biology of cancer epigenetics. Cell Chem. Biol. 24, 1120–1147 (...
proteins and DNA (so-called epigenetic modifications) for transcriptional control and normal development. Disruption of epigenetic control is a frequent event in disease, and the first epigenetic-based therapies for cancer treatment have been approved...
A plethora of groundbreaking studies have demonstrated the importance of chromatin-associated proteins and post-translational modifications of histones, proteins and DNA (so-called epigenetic modifications) for transcriptional control and normal developm
Current drug targets 10, 442-454.Unoki M, Kumamoto K and Harris CC: ING proteins as potential anticancer drug targets. Curr Drug Targets 10: 442-454, 2009.Unoki M, Kumamoto K, Harris CC. ING proteins as potential anticancer drug targets. Curr Drug Targets. 2009; 10 :442–454....
Small-molecule drugs to therapeutically exploit the SWI/SNF complex Epigenetic proteins have been intently pursued as targets for cancer therapy. However, it was thought that SWI/ SNF complex proteins were not good targets for cancer therapy due to the tumor suppressor activities of the Schiaffino-...
Drug discovery Scaffold proteins Cancer Allodynia Infectious diseases Anesthesia Introduction The stomatin/prohibitin/flotillin/HflK/HflC (SPFH) domain, also known as the prohibitin homology (PHB) domain or Band-7 domain, is composed of an approximatively 200-amino acid motif of ancient origin. This...
Integrin‐associated proteins as potential therapeutic targets Summary: Integrins are adhesion receptors important for hematopoiesis, leukocyte trafficking, and formation of immunological synapses; hence, they may pro... JM Cantor,MH Ginsberg,DM Rose - 《Immunological Reviews》 被引量: 124发表: 2008年 ...
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 10, 945–963 (2011). https://doi.org/10.1038/nrd3599 Download citation Published01 December 2011 Issue DateDecember 2011 DOIhttps://doi.org/10.1038/nrd3599 Subjects Cancer Cardiovascular ...