CXCR4 expression on activated B cells is downregulated by CD63 and IL-21. J Immunol. 2011; 186 :2800–2808.Yoshida N, Kitayama D, Arima M, Sakamoto A, Inamine A, Watanabe-Takano H, Hatano M, Koike T, Tokuhisa T. CXCR4 expression on activated B cells is downregulated by CD63 and...
Restimulation of activated B cells with IL-21, which is a major cytokine produced by T follicular helper cells, accelerated CXCR4 internalization by inducing endocytosis-related GRK6 expression. Although CXCR4 expression was downregulated on GC B cells by IL-21 stimulation, CXCR4(low) centrocy...
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depleted of neutrophils and macrophages, and larvae injected with control morpholino (68% inhibition). Two-tailed un-paired t-test with Welch’s correction (****p < 0.0001) was performed on a pool of two biological replicates (Control: n = 84,...
Furthermore, we showed that the abrogation of CXCR4 had significantly negative influence on the IHCC cell phenotype, including in vitro cell proliferation, cell cycle, colony formation, cell invasion, and in vivo tumorigenicity. In addition, CXCR4 knockdown downregulated Wnt target genes and ...
The p values described in the in vitro assays are based on t tests (two-tailed; α 0.05). p values are provided for each figure. The average of experiments performed in triplicate is shown. The Kaplan-Meier curve was obtained using GraphPad Prism, and the p value was calculated based on...
We sequentially transduced MLL-AF9 leukemia cells with Cxcr4 sgRNA_b coexpressing tRFP657 and Cxcr4 cDNAs coexpressing GFP, which resulted in restored CXCR4 expression on the cell surface (Figures 7A and 7B; Figure S7B). As anticipated, leukemia cells expressing Cxcr4D99G or Cxcr4L251P ...
nase),但不能激活p38或JNKMA_PK(Mito—activated proteinkinase).SDF一1诱导的细胞也不能被MEK抑 制剂PD98059阻断,考虑MEK可能在SDF一1/CXCR4 诱导的细胞内信号转导中起调节作用. 4结束语 SDF一1和CXCR4的特异性结合及其所启动的下 游信号通路在细胞的胚胎发育,造血,免疫及HIV治疗 上具有重要的意义,对具体的...
CXCL12基因位于 10号染 mTOR路径的调节下,CXCL12/CXCR4生物轴 (CXCL12/CX— 色体长臂,而其他趋化因子的基因位于4号、17号染色体。 CR4biologicalaxis)能促进纤维细胞增殖、肌成纤维细胞形 CXCL12cDNA长 1776bp,其非编码区富含A+T序列,编码 成、细胞外基质沉积,加速肺纤维化发病进程。该文将就 区仅含有 1个...
Restimulation of activated B cells with IL-21, which is a major cytokine produced by T follicular helper cells, accelerated CXCR4 internalization by inducing endocytosis-related GRK6 expression. Although CXCR4 expression was downregulated on GC B cells by IL-21 stimulation, CXCR4low centrocytes ...