Downregulated by CD63 and IL-21 CXCR4 Expression on Activated B Cells Is CXCR4 expression is critical for localization of centroblasts in the dark zone of germinal centers (GCs), and centrocytes downregulate CXCR4 and thus leave... T Tokuhisa,Watanabe-Takano,M Hatano,... 被引量: 0发表...
CXCR4 expression on activated B cells is downregulated by CD63 and IL-21. J Immunol (2011) 186(5):2800-8. doi:10.4049/ jimmunol.1003401Yoshida N, Kitayama D, Arima M, Sakamoto A, Inamine A, Watanabe-Takano H, Hatano M, Koike T, Tokuhisa T. CXCR4 expression on activated B ...
nase),但不能激活p38或JNKMA_PK(Mito—activated proteinkinase).SDF一1诱导的细胞也不能被MEK抑 制剂PD98059阻断,考虑MEK可能在SDF一1/CXCR4 诱导的细胞内信号转导中起调节作用. 4结束语 SDF一1和CXCR4的特异性结合及其所启动的下 游信号通路在细胞的胚胎发育,造血,免疫及HIV治疗 上具有重要的意义,对具体的...
To elucidate the mechanisms by which CXCR4 antagonism reduces AF inducibility, we evaluated the effect of CXCR4 on the alteration of CD3+ T lymphocytes, CD20+ B lymphocytes and F4/80+ macrophages in the atria using IHC. The infiltration of CD3+ lymphocytes in atria was markedly increase...
and confirmed CXCR4 as M2 marker7. It has been shown that CXCR4 can also be activated by alternative ligands like MIF (Macrophage Migration Inhibitory Factor)8. MIF signalling has been associated to inflammatory diseases. Upon binding to CXCR4 or CXCR2, MIF controls monocyte and T cell chemot...
(P < 0.01) but had no impact on FOPflash activity (Figure4A). Moreover, QT–PCR analysis showed that Wnt target genes such as β-catenin, c-myc, and CD44 were decreased in shCXCR4-3 cells but increased when activated by CXCL12 (Figure4B). Meanwhile, the inhibition of CXCR4 ...
We sequentially transduced MLL-AF9 leukemia cells with Cxcr4 sgRNA_b coexpressing tRFP657 and Cxcr4 cDNAs coexpressing GFP, which resulted in restored CXCR4 expression on the cell surface (Figures 7A and 7B; Figure S7B). As anticipated, leukemia cells expressing Cxcr4D99G or Cxcr4L251P ...
Downregulated by CD63 and IL-21 CXCR4 Expression on Activated B Cells Is CXCR4 expression is critical for localization of centroblasts in the dark zone of germinal centers (GCs), and centrocytes downregulate CXCR4 and thus leave... T Tokuhisa,Watanabe-Takano,M Hatano,... 被引量: 0发表...
Such low response was not due to “saturation” of the pathway, since these cascades were robustly activated upon EGF stimulation, proving these pathways are still on dynamic range of stimulation. Interestingly, pharmacological inhibition of CXCR4 or (to a lesser extent) ACKR3 diminished AKT and ...
Such low response was not due to “saturation” of the pathway, since these cascades were robustly activated upon EGF stimulation, proving these pathways are still on dynamic range of stimulation. Interestingly, pharmacological inhibition of CXCR4 or (to a lesser extent) ACKR3 diminished AKT and ...