TCR independent, CD31-driven induction of these cytokines suggests maladaptive T cell function in JIA. Further investigation on the relevance of IFN and IL-17 to disease activity/clinical outcomes, and the CD31 signaling pathway will pave way to innovations in immunotherapy in JIA....
Using these two independent systems, we show that T cell activation can be impaired by mutations that either decrease or increase the binding half-life of the TCR-pMHC interaction. Our data indicate that efficient T cell activation occurs within an optimal dwell-time range of TCR-pMHC ...
Overall, we describe a spectrum of TCR-dependent T cell activation patterns in this scRNA-seq dataset from an ex vivo restimulation setting from patient-derived neoantigen-specific CD8+T cells. We detected cytotoxic, proliferative and less inhibitory T cell activation patterns, especially for KIF-P1...
Synthetic T cell receptor and antigen receptor-T (STAR-T) integrates the advantages of CAR-T and TCR-T, is an MHC-independent high-affinity TCR-T. STAR is an antibody-TCR chimera, in which TCR constant regions are ligated with variable regions of heavy and light chains of antibody. In o...
In addition to ‘adhesion-induced T-cell priming’, a distinct and important type of T-cell priming should be considered, which could be called ‘T-cell priming by self-peptides’. Stefanova et al. have recently demonstrated that in vivo, antigen-independent T-cell interactions with APCs tran...
activation of MAIT cells leads to an upregulation of gene signatures associated with tissue repair21,22,23, while cytokine-mediated activation enhances the expression of cytotoxic molecules in MAIT cells14,24. This implies that the mode of MAIT cell activation might determine their dichotomous ...
which offers a robust and efficient system for engineering these advanced cellular therapies. The innovative CAR × TCR bispecific T cells leverage the unique abilities of both CARs and TCRs to maximize anti-tumor efficacy. CARs provide MHC-independent targeting of cell surface antigens through high...
Rapid activation-induced CTLA-4 surface expression in mouse CD4+CD25+ T cells is independent of protein synthesis and Rab-27a. When antigen-dependent T-cell-antigen-presenting cell (APC) conjugates were analysed for surface distribution of CD86 on APC, a higher concentration of CD86 molecules was...
Memory T cells targeting the mutated KRAS G12D and KRAS G12V have also been identified and isolated with 4-1BB as the T-cell activation marker in another study [117]. CD39, a transmembrane extracellular ATPase, is widely expressed by regulatory T cells, B cells, and some tumor cells. ...
Objectives: Adoptive cancer immunotherapy (ACT) with transgenic T cell receptor (TCR) engineered (TCReng) anti-tumor T cells has produced encouraging results, however, efficacy of these approaches need improvement. Since premature activation induced cell death (AICD) of adoptively administered T cells...