Gangliosides elicit a T-cell independent antibody response. J Autoimmun. 1993; 6(3) 281-289.Freimar, M., McIntosh, K., Adams, R., Alving, C., Drachman, D. (1993) Gangliosides elicit a T-cell independent antibody
Vaccines generally require T lymphocytes for B-cell activation and immunoglobulin class switching in response to peptide or protein antigens. In the absence of T cells, limited IgG class switch takes place, germinal centers are short-lived, and the B cel
et al. Cutting edge: the IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: exploring the role of GPIs in NK T cell activation and antimalarial responses. J. Immunol. 164, 5005–5009 (2000). CAS PubMed Google Scholar Romero, J. F., Eberl, G...
Our data provide novel insight into the immune response to RV infection providing first in vivo evidence of the importance of IL-15 for NK-cell, CD8+ T-cell, and CD4+ T-cell responses to RV infection. In addition, we have identified a novel function for IL-15 in augmenting antiviral IFN...
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Molnarfi, N. et al. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.J. Exp. Med.210, 2921–2937 (2013). CASPubMedPubMed CentralGoogle Scholar Kowarik, M. C. et al. Differential effects of fingolimod (FTY72...
Other cytokines, such as TNFα, IL-15, and IL-18 further augment the CD8+ T cell response. Role in anti-tumor immunity: CD8+ T cells are considered major drivers of anti-tumor immunity [3]. CD8+ tumor-infiltrating lymphocytes (TILs) mediate tumor rejection ...
2024年5月8日,中国科学院上海营养与健康研究所肖意传研究员团队联合南京医科大学附属江苏省肿瘤医院和复旦大学附属肿瘤医院的戴东方、黄明主和陈小祥主任医师在Cell Reports Medicine上联合发表了文章Chemoradiotherapy-induced ACKR2+tumor cells d...
providing information on the role of CAR T-cell clonotypic phenotypes in driving the immune response [42,43,44]. By inserting sequencing adapters into accessible regions of the genome with Tn5 transposase, scATAC-seq allows the measurement of genome-wide open chromatin regions to identify both ac...
3d). Neither CD4+ T cell population proliferated significantly in naive mice, suggesting that TCR 1 does not recognize the wild-type CLTC epitope in vivo despite producing IFN-γ in response to splenocytes pulsed with high concentrations of the corresponding peptide (Figs. 3d and 1f). ...