Delayed type hypersensitivity (DTH) is a T-cell dependent inflammatory response at the site of antigen deposition, usually in the skin. It reaches its peak intensity 24鈥 48 h after initiation and is characterized by a mononuclear cell infiltration. T cells, but not B cells nor immune serum,...
CD8+ T 细胞的抗肿瘤反应受到不同的代谢适应性的严格调控。在大多数肿瘤中都能观察到高水平的谷胱甘肽(GSH),它在一定程度上通过阻止谷胱甘肽过氧化物酶 4依赖性(GPX4-dependent)铁死亡来促进癌症的进展和抗药性。在这里,我们展示了腺苷 A2A 受体(A2AR)信号传导和 GSH/GPX4 轴在协调有功能的 CD8+ T 细胞的代谢适...
1、T cell mediated immune responseT细胞介导的免疫应答皮质髓质皮髓质交界处胸腺细胞皮质上皮细胞髓质上皮细胞DC细胞巨噬细胞胸腺的结构T细胞的发育骨髓胎肝胸腺皮质 髓质外周T细胞来源于骨髓, 在胸腺中”受训”胸腺中的T细胞,循DN细胞、DP细胞、SP细胞的三个主要阶段进行发育皮质区胸腺上皮细胞对DP细胞进行阳性选择...
T cell dependent antibody response tests [M] . // Herzyk DJ and Bussiere J. Immunotoxicology Strategies For Pharmaceutical Safety Assessment. John Wiley. Sons, Inc. , Hoboken, New Jersey, 2008:67-76.Piccotti J R. T cell dependent antibody response tests[A].John Wiley and Sons,Inc,...
近期,有研究在对 2 例晚期难治性骨髓瘤和 1 例转移性肉瘤的治疗中,结合成簇规律间隔的短回文重复序列及其相关蛋白 9(clustered regularly interspaced short palindromic repeat/CRISPR associated protein 9,CRISPR-Cas9)敲除内源性 TCR...
The T cell response is an integral and essential part of the host immune response to acute virus infection. Each viral pathogen has unique, frequently nuanced, aspects to its replication, which affects the host response and as a consequence the capacity of the virus to produce disease. There ...
4.Cell Host Microbe(31.3)| 2024.03.13 | Gut microbe guides alveolar macrophages to fight flu.(肠道微生物引导肺泡巨噬细胞对抗流感) 肠道微生物群与防御呼吸道病毒感染有关。本研究表明,肠道共生分段丝状细菌可重新编程肺泡巨噬...
Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 12, 269–281 (2012). https://doi.org/10.1038/nri3191 Download citation Published22 March 2012 Issue DateApril 2012 DOIhttps://doi.org/10.1038/nri3191 Subjects Cancer immunotherapy Gene targeting Immunotherapy T ...
et al. Robust antigen specific TH17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. PLoS Pathog. 7, e1002252 (2011). Article CAS PubMed PubMed Central Google Scholar Cooper, A. M. et al. Disseminated tuberculosis in interferon gamma gene...
Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens Techniques which identify hapten-specific B cells in tissues have been used to determine the sites of B cell activation in rat spleens in response to T cel... YJ Liu,...