infection preventing the induction of fully protective and long-lived antibody-mediated immunity to The objective of this dissertation was therefore to determine the quality of the T-dependent humoral immune response to and to study the induction and functionality of the CD4 T helper cell response.Elsner, Rebecca Ann
Increased numbers of T follicular helper (Tfh) cells have been implicated in the development of autoimmune diseases including primary Sjögren’s syndrome (pSS), but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear. Here, we first found negative correlation...
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The modulation of B-cell antigenicity by Tregs in a CD4+ T-cell-dependent manner that contributed to the control of RSV-induced pathogenesis was confirmed. 2. Materials and methods 2.1. Animals, cell lines, and viruses Six- to eight-week-old BALB/c (H-2Kd) and CB17scid (SCID) mice ...
During infection with chikungunya virus (CHIKV), an emerging alphavirus, anti-CD137 mAb treatment resulted in reduced numbers of GC B cells, MBCs, and LLPCs. Administration of agonistic anti-CD137 mAb also dampened the serum antibody response in mice immunized with other T-cell-dependent ...
Mayya V, Dustin M L. What scales the T cell response?[J]. Trends Immunol, 2016, 37(8): 513-522. Smith E L, Staehr M, Masakayan R, et al. Development and evaluation of an optimal human single-chain variable fragment-derived BCMAtargeted...
9. Y. Wu, et al. A local human Vdelta1 T cell population is associated with survival in nonsmall-cell lung cancer Nat. Cancer, 3 (2022), pp. 696-709 10. G. Germano, et al. CD4 T cell-dependent rejection of beta-2 microglo...
CD8+ T 细胞的抗肿瘤反应受到不同的代谢适应性的严格调控。在大多数肿瘤中都能观察到高水平的谷胱甘肽(GSH),它在一定程度上通过阻止谷胱甘肽过氧化物酶 4依赖性(GPX4-dependent)铁死亡来促进癌症的进展和抗药性。在这里,我们展示了腺苷 A2A 受体(A2AR)信号传导和 GSH/GPX4 轴在协调有功能的 CD8+ T 细胞的代谢适...
The capacity of Leishmania donovani-infected BALB/c mice to respond to conventional chemotherapy with pentavalent antimony (Sb) is T cell dependent and, in nude mice, can be restored in part by treatment with the T celllymphokines, interferon-γ (IFN-γ) or interleukin-2 (IL-2). Todocument...