近年来学者鉴定出一种新型辅助性T细胞亚群,被命名为外周辅助性T(Tph)细胞,其表型被定义为程序性死亡受体1(PD-1) hiCXCR5 -CD4 + T,该细胞可促进B细胞分化成熟、分泌抗体,功能上类似滤泡辅助性T(Tfh)细胞。与Tfh细胞不同的是,Tph细胞以高表达PD-1,不表达CXCR5和Bcl-6为表型特征。目前研究发现Tph细胞在RA、...
1.2.3 流式细胞技术检测 CXCR5+CD4+T 淋巴细胞 (TFH) 使用 EDTA 抗凝管采集各组受试者清晨空腹 外周静脉血 4 mL,采用 Ficoll 密度梯度离心法分离得 到外周血单个核细胞(peripheral blood mononuclear cells, PBMCs),以 PBS 重悬并调整为 1×106 个/mL,加入抗体 CXCR5 - APC,CD4-PerCP,CD3 - FITC,PD1 ...
CXCR5+CD4+ T cells (including T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr)) are responsible for the regulation of B cell functions. The aim of this study was to dissect the roles of CXCR5+CD4+ T cell subset in B cell disruption caused by HBC. Methods: 41 ...
滤泡外PD-1highCXCR5-CD4+ T细胞参与鼻息肉局部免疫球蛋白的产生 Extrafollicular PD-1highCXCR5-CD4+ T cells participate in local immunoglobulin production in nasal polyps 新研究证据表明局部免疫球蛋白过度产生,在伴有鼻息肉的慢性鼻...
2019年9月17日,美国宾夕法尼亚大学的Laura F. Su团队在Cell Reports上发表长文Mapping the lineage relationship betweenCXCR5+andCXCR5-CD4+T cells in HIV infected human lymph nodes(本文的共同第一作者为Daniel Del Alcazar和Yifeng Wang)。这项研究揭示了在被HIV感染的淋巴结中,滤泡辅助性T细胞会失去CXCR5的...
The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++ CD4+ T cells (TFH cells). We investigated the ontogeny of CXCR5+PD-1++ CD4+ T cells in human intestines. While CXCR5+PD-1++ CD4+ T cells were absent in fetal...
Although a fraction of human blood memory CD4+T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established. Here we show that human blood CXCR5+CD4+T cells share functional properties with Tfh cells an...
以此同时,CXCR5 CAR对大量患者来源的原发性B细胞淋巴瘤(包括FL、B-CLL、MCL和MZL)的原代细胞,以及滤泡T辅助细胞(Tfh,选择CD4+CXCR5+T辅助细胞作为替代细胞),均具有特异的效应功能,可以诱导强烈的IFN-γ释放,并在大多数情况下优于...
CD4+CXCR5+ follicular helper T (Tfh) cells, via interleukin (IL)-21 secretion, activate B cells. However, the role of CD4+CXCR5+ T cells in the activation of IgG+ B cells in CHC patients is not clear. METHODS: The frequency of IgG+ B cells, including CD27−IgG+ B and CD27+IgG...
Follicular helper CD4 T cells (TFH). T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of immunological memory. Follicular helper CD4 T (T(FH)) cells are t... S Crotty - 《Annual Review of Immunology》 被引量: 2977发表: 2011年 The transcriptional ...