尽管 Tem 通常缺乏 CD27 和 CD28 的表达,但在一些报告中显示,外周血 CD8 + T 细胞亚群在表型上介于 TSCM/CM 和 Tem 之间,被称为过渡记忆(T TM细胞),这些细胞在 HIV 特异性 CD8 + T 细胞中特别多见,其CCR7 和 CD62...
尽管 Tem 通常缺乏 CD27 和 CD28 的表达,但在一些报告中显示,外周血 CD8 + T 细胞亚群在表型上介于 TSCM/CM 和 Tem 之间,被称为过渡记忆(T TM细胞),这些细胞在 HIV 特异性 CD8 + T 细胞中特别多见,其CCR7 和 CD62L 下调,但仍表达 CD27 和/或 CD28。 随着人类年龄的增长,效应记忆 CD8 + T 细胞...
Production of effector CD8+ Tcells during persistent infection requires a stable pool of stem-like cells that can give rise to effector cells via a proliferative intermediate population. In infection models marked by Tcell exhaustion, this process can be transiently induced by checkpoint blockade but...
近日,美国加利福尼亚大学的Michel DuPage研究团队在Immunity杂志在线发表题为CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity的研究文章。该论...
TGFβ has a role in cancer immunosuppression but the exact mechanisms haven't been fully elucidated. Here, using mouse models deficient in TGFβ-signaling, the authors show that loss of ALK5 in CD8 + T cells enhances their tumour trafficking and cytotoxicity suggesting that ALK5 inhibitors may...
Using a vaccinia virus (VV) mouse ear-infection model, we defined a central role for CD8+ T cells in clearing mobile virus-infected inflammatory monocytes (Hickman et al., 2013). Although adept at eliminating this subset of infected cells, CD8+ T cells only reluctantly entered compact foci ...
Type 1 TREG cells promote the generation of CD8+ tissue resident memory T cells Tissue-resident memory T (T) cells, functionally distinct from circulating memory T cells, have a critical role in protective immunity in tissues, are more efficacious when elicited after vaccination and yield more ef...
021).Conclusion The counts of peripheral CXCR3+CD8+T cells decreased significantly in ACLF,and it might be associated with poor clinical outcomes. 展开 关键词: hepatitis B virus liver failure adaptive immunity CXC chemokine receptor 3 被引量: 2 ...
CD8+T cells can occur in the context of spatially localized inflammation. We demonstrate that bystander activation during localized inflammation hinges on the ability of memory CD8+T cells to rapidly migrate to sites of early immune activation in a CXCR3-dependent manner. Thus, our data suggest ...
The tumors of the cohort which had received two therapy cycles showed a significant increase in CD3+ T cells as well as in the CD8+ T cell fraction (see Fig. 1E). This cohort also exhibited a global increase in CXCR3+ lymphocytes (8.7 ± 6.6 vs. 41.7 ± 20.5 CXCR3+ ...