近日，AASLD 2022大会摘要发表重庆医科大学附属第二医院胡鹏教授团队的一项研究，证明表达CXCR5+ CD8+ T细胞亚群的免疫活性高，产生免疫相关因子水平更高，有助于慢乙肝患者病毒血症的控制，可能为慢乙肝临床治愈提供潜在的免疫治疗靶点。研究背景CD8+ T细胞耗竭是慢性HBV感染的主要原因之一，同时CD8+ T细胞存在明显的表型...
近日,AASLD 2022大会摘要发表重庆医科大学附属第二医院胡鹏教授团队的一项研究,证明表达CXCR5+ CD8+ T细胞亚群的免疫活性高,产生免疫相关因子水平更高,有助于慢乙肝患者病毒血症的控制,可能为慢乙肝临床治愈提供潜在的免疫治疗靶点。 研究背景 CD8+ T细胞耗竭是慢性HBV感染的主要原因之一,同时CD8+ T细胞存在明显的表型和...
CD8+ T cells were analyzed (n = 4 or 3). f, Chromatinimmunoprecipitation(ChIP) and quantitative PCR (qPCR) of the binding of E2A to Cxcr5 (chr9:44266001-44267000) loci (n = 3). g, me3H3K4 and me3H3K27 modifications on the Cxcr5 loci (n = 3). The data are representative of ...
CD8 T cells, these cells were separated from TILNs and were TCR-stimulated via anti-CD3/CD28. Upon stimulation, CXCR5+CD8 T cells presented stronger downregulation of CD27, higher expression of proinflammatory cytokines IL-2, IFN-γ, and TNF-α, and higher proliferation capacity than CXCR5?
在一项新的研究中,来自美国埃默里大学耶基斯国家灵长类动物研究中心的研究人员鉴定出一群抗病毒T细胞具有到达生发中心的进入密码,即一种被称作CXCR5的分子。相关研究结果即将发表在PNAS期刊上,论文标题为“Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection”。
据出国看病领导品牌厚朴方舟获悉,在一项新的研究中,来自美国埃默里大学耶基斯国家灵长类动物研究中心的研究人员鉴定出一群抗病毒T细胞具有到达生发中心的进入密码,即一种被称作CXCR5的分子。相关研究结果即将发表在PNAS期刊上,论文标题为“Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection”。
These CD8 Tfh cells regulate the germinal center B cell response and control autoantibody production, as deficiency of Stat5 in CD8 T cells leads to an increase of CD8 Tfh cells, resulting in the breakdown of B cell tolerance and concomitant autoantibody production. CD8 Tfh cells share similar ...
These proof of principle results open a pathway for directing engineered antiviral T cells into these viral sanctuaries to help eliminate this source of persistent virus. 展开 关键词: B-cell follicles CD8 T cells CXCR5 T-cell homing DOI: 10.1128/JVI.02507-16 ...
MicroRNA regulation of CD8 T cell responses(MicroRNA调节CD8 T细胞反应) 热度: Caspase-8 restricts antiviral CD8 T cell hyperaccumulation(Caspase-8限制抗病毒CD8 T细胞过度积累) 热度: Mast Cells Inhibit CD8 T Cell-Mediated Rejection of a… 热度: 相关推荐 JVI02507-161 CXCR5DependentEntryofCD8...
The finding that a subset of early effector memory CD8 T cells use CXCR5 to locate to B cell follicles indicates that MHC class I-restricted CD8 T cells are part of the follicular T cell population. 展开 关键词: B cells CD8 T cells Chemokines CXCR5 T cells ...