近日，AASLD 2022大会摘要发表重庆医科大学附属第二医院胡鹏教授团队的一项研究，证明表达CXCR5+ CD8+ T细胞亚群的免疫活性高，产生免疫相关因子水平更高，有助于慢乙肝患者病毒血症的控制，可能为慢乙肝临床治愈提供潜在的免疫治疗靶点。研究背景CD8+ T细胞耗竭是慢性HBV感染的主要原因之一，同时CD8+ T细胞存在明显的表型...
近日,AASLD 2022大会摘要发表重庆医科大学附属第二医院胡鹏教授团队的一项研究,证明表达CXCR5+ CD8+ T细胞亚群的免疫活性高,产生免疫相关因子水平更高,有助于慢乙肝患者病毒血症的控制,可能为慢乙肝临床治愈提供潜在的免疫治疗靶点。 研究背景 CD8+ T细胞耗竭是慢性HBV感染的主要原因之一,同时CD8+ T细胞存在明显的表型和...
Moreover, CXCR5+CD8 T cells presented higher expression of cytotoxic molecules Gzm-A, Gzm-B, and perforin. Overall, these results demonstrated that in thyroid cancer patients CXCR5+CD8 T cells infiltrated the TILNs and the tumors, and were functionally more potent compared to their CXCR5-...
CD8+ T cells were analyzed (n = 4 or 3). f, Chromatinimmunoprecipitation(ChIP) and quantitative PCR (qPCR) of the binding of E2A to Cxcr5 (chr9:44266001-44267000) loci (n = 3). g, me3H3K4 and me3H3K27 modifications on the Cxcr5 loci (n = 3). The data are representative of ...
据出国看病领导品牌厚朴方舟获悉,在一项新的研究中,来自美国埃默里大学耶基斯国家灵长类动物研究中心的研究人员鉴定出一群抗病毒T细胞具有到达生发中心的进入密码,即一种被称作CXCR5的分子。相关研究结果即将发表在PNAS期刊上,论文标题为“Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection”。
CD8 cells which are largely excluded (1). Indeed, most of the residual virus in otherwise 83 o n M a r c h 2 3 , 2 0 1 7 b y T O N G J I U N I V E R S I T Y h t t p : / / j v i . a s m . o r g / D o w n l o a d e d f r o m 5 ...
These proof of principle results open a pathway for directing engineered antiviral T cells into these viral sanctuaries to help eliminate this source of persistent virus. 展开 关键词: B-cell follicles CD8 T cells CXCR5 T-cell homing DOI: 10.1128/JVI.02507-16 ...
Follicular CXCR5-expressing CD8(+) T cells curtail chronic viral infection[J]. Nature, 2016,537(7620):412-428. DOI: 10.1038/nature19317 . 返回引文位置Google Scholar 百度学术 万方数据 [4] Miles B , Miller SM , Folkvord JM ,et al. Follicular Regulatory CD8 T Cells Impair the Germinal ...
趋化因子受体CXCR5是CAR-T细胞治疗的一个卓越靶点,因为CXCR5表达于成熟B细胞、恶性B细胞和肿瘤辅助性滤泡T辅助细胞(Tfh)上,而在骨髓内的B细胞前体或浆细胞上不表达。2021年1月,《自然通讯》发表了题为“CXCR5 CAR-T cells simultan...
CXCR5(+) CD8(+) T cells present elevated capacity in mediating cytotoxicity toward autologous tumor cells through interleukin 10 in diffuse large B-cell ... PXB Tang - 《International Immunopharmacology》 被引量: 0发表: 2017年 CXCR5 + CD8 + T cells present elevated capacity in mediating cytotox...