Although surface marker analysis demonstrated that both CXCR6+and CXCR6CD4+T-cell subsets consist of the cells with effector and effector-memory cells, the more cells in the CXCR6+subset produced IFN-纬 and TNF-伪 compared to CXCR6subset, and only the CXCR6+subset produced IL-17A. ...
CXCR6在NK和CD4+T细胞中也有表达，但是丰度很低。用流式检测发现在肿瘤生长的第18天时，CTLs中表达最高的趋化因子受体是CXCR6。在PD-1+干细胞样CTLs和PD-1+效应CTLs中CXCR6都高表达，后者丰度最高。利用CXCR6敲除小鼠构建移植肿瘤模型发现，敲除CXCR6导致肿瘤生长迅速，抗肿瘤免疫反应遭到损害。而如若在对照组...
2021年8月2日,美国哈佛学院的Mauro Di Pilato博士等人在《Cell》上发表了一篇“CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment”的文章。 免疫系统成功清除病毒感染取决于识别细胞内病原体衍生抗原的CD8+T细胞。淋巴组织中幼稚细胞的克隆扩增产生短寿命效应细胞,...
4. DC3s密集地聚集在肿瘤基质的富含T细胞的血管周围壁龛中; 2021年8月2日,美国哈佛学院的Mauro Di Pilato博士等人在《Cell》上发表了一篇“CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment”的文章。 免疫系统成功清除病毒感染取决于识别细胞内病原体衍生抗原的...
However, the molecular mechanisms that control CD4 T cell effector functions and lead to the development of autoimmune diseases are not well understood. A self-antigen and heat-killed Mycobacterium tuberculosis emulsified in IFA augmented the activation of CD4 T cells, leading to the differentiation ...
cDC1s更有效地将肿瘤细胞衍生的抗原交叉呈递给CTLs，而cDC2s可能与CD4+T细胞激活更相关。一种名为DC3的肿瘤内DC状态被发现，其特征是IL12b、Fascin1和趋化因子受体基因CCR7的共表达。对TME中趋化因子及其受体的分析揭示了CXCR6在肿瘤浸润CTL中的显著表达及其在促进维持CD8+T细胞介导的肿瘤免疫控制的血管...
Infected CXCR6 deficient mice displayed a reduced accumulation of CD4+ T cells in the liver; adoptive transfer experiments suggested that the reduction of CD4+ T cells in the liver was attributed to a cell intrinsic property of CXCR6 deficient CD4+ T cells. Importantly, infected CXCR6 deficient...
We specifically checked the cell surface marker of CD8+ T cells. We only kept cells with either CD8A or CD8B expression. To distinguish from the CD4+ TRM, we excluded the cells (9 cells) with CD4 expression. Overall, we kept 1, 101 CD8+ TRM cells (765 from moderate patients and 336...
conjunction with CD4. 关键字:CXCR6;CXCR6蛋白;CD186蛋白;ACRO;百普赛斯; 公司简介 百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北...
Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different...