CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. Blood. 2015;125(13):2087-2094.ArietaKuksin, C., Gonzalez-Perez, G. & Minter, L. M. CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a ...
Also, the expression of CXCR4 is impacted by interleukin-5 (IL-5), interferon-γ (IFN-γ) [61], and transforming growth factor-β (TGF-β) [62], secreted by stromal cells and interleukin-17A (IL-17A) [63], released by T cells. IFN-γ and IL-5 have a reverse influence on CXCR...
BioMed CentralPage 1 of 9(page number not for citation purposes)BMC CancerOpen AccessResearch articleCXCR4 expression on circulating pan-cytokeratin positive cells is associated with survival in patients with advanced non-small cell lung cancerKaren L Reckamp*1,2, Robert A Figlin1, Marie D Burdic...
Cutting Edge: IL-4 Induces Functional Cell-Surface Expression of CXCR4 on Human T Cells1 Cutting edge: IL-4 induces functional cell-surface expression of CXCR4 on human T cells. J. Immunol. 160:4153.Jourdan, P., Abbal, C., Nora, N... P Jourdan,C Abbal,N Nora,... - 《Journal...
we find that Cxcr4 promotes initial monocyte infiltration and subsequent territorial restriction of monocyte-derived macrophages to infarct tissue. After transient focal ischemia,Cxcr4deficiency reduces monocyte infiltration and blunts the expression of pattern recognition and defense response genes in monocyte...
, we investigated the immunomodulatory effects of P-BS-CM1 → P-CM2 on primary tumors (Supplementary Fig. 16a). Flow cytometry of immune cells in primary tumor tissues showed that immunosuppressive regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) were not affected by...
In HepG2 cells, CXCR4 was almost undetectable but was associated with clear CXCR7 expression, although no functional migration was observed in the presence of the ligand CXCL12. This could be explained by receptor resistance, as previously described for HepG2, Daudi and Raji lymphoma cells.29,...
Moreover, expression of CXCR4 on cancer cells was associated with cancer stem cell phenotype and treatment resistance [29]. Previously, it was showed that CXCR4 is involved in homing of breast cancer cells predominantly to bone and liver [30, 31], however, this is a first study that ...
Transfect the experimental group with the reporter gene, target gene expression vector, TK vector, and the control group with the reporter gene, empty vector, TK vector into HEK293T cells. After incubation, lyse the cells and measure the firefly and Renilla luciferase activities using a ...
On the other hand, membrane CXCL12 immunostaining is probably due to the binding of exogenous protein to its main receptor CXCR4. Immunofluorescence and IHC have shown that CXCL12 is expressed most likely in the tumor cells and expression rates of 70.9% [44], 66.8% [31] or 70.6% [43] in...