CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. Blood. 2015;125(13):2087-2094.ArietaKuksin, C., Gonzalez-Perez, G. & Minter, L. M. CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a ...
CXCR4 expression on transplanted peripheral blood CD34+ cells: relationship to engraftment after autologous transplantation in a cohort of multiple myeloma... CXCR4 expression on transplanted peripheral blood CD34+ cells: relationship to engraftment after autologous transplantation in a cohort of multiple ...
BACKGROUND: Signaling through stromal cell-derived factor-1α (SDF-1α), strongly secreted by bone marrow stromal cells and the CXC chemokine receptor 4 (CXCR4) exposed on tumor cells has pivotal roles in proliferation, metastasis, and tumor cell "dormancy." Dormancy is associated with cytostati...
We, therefore, strongly recommend the use of non-enzymatic dissociation methods, followed by filtration through a cell strainer to obtain single cell suspensions, in order to preserve maximal CXCR4 expression and optimal homing of cells.doi:10.1007/s12185-020-03043-0Pervin, Burcu...
Resistance to antiangiogenic therapy in glioblastoma (GBM) patients may involve hypoxia-induced expression of C-X-C motif chemokine receptor 4 (CXCR4) on invading tumor cells, macrophage/microglial cells (MGCs), and glioma stem cells (GSCs). We determined whether antagonizing CXCR4 with POL5551...
Lower panel, representative photographs of stained cells on the lower side of matrigel membrane from one of three experiments. Original magnifications, 100×. Full size image Hypoxia and CXCR4 signaling increase MMP1 expression and activity Cell invasion is in part mediated by matrix ...
Low CXCR4 membrane expression on CD34+ cells characterizes cells mobilized to blood. Dlubek, D, Drabczak-Skrzypek, D, Lange, A (2006) Low CXCR4 membrane expression on CD34(+) cells characterizes cells mobilized to blood. Bone Marrow... Dlubek,D.,Drabczak-Skrzypek,... - 《Bone Marrow...
Objective: To evaluate the expression of CXCR4 and the migration rate of bone marrow CD34+ cells in different myelodysplastic syndrome (MDS) risk groups and to perform the correlation analysis between the expression of CXCR4 and the migration rate of CD34+ cells. Methods: A total of 40 patient...
SDF-1 was mainly localized on the cell membrane Full size image Comparison of CXCR4, CXCR7 and SDF-1 expression between carcinoma and the surrounding tissues The expression of CXCR4, CXCR7 and SDF-1 between carcinoma tissues (CT) and the surrounding tissues (ST) was compared. The expression...
The von Hippel–Lindau tumor suppressor protein pVHL negatively regulates CXCR4 expression by targeting HIF for degradation under normoxic conditions36. In addition, CXCR4 is expressed on monocytes, B cells, and naive T cells37,38. CXCR4 is produced by all subsets of B cells and plays a role...