Cullin-RING ubiquitin ligases: global regulation and activation cycles. Cell Div. 2008; 3 :7. doi: 10.1186/1747-1028-3-7. [ Cross Ref ]Bosu D.R., Kipreos E.T. Cullin-RING ubiquitin ligases: Global regulation and activation cycles. Cell Div. 2008; 3 :7. doi: 10.1186/1747-1028-3-...
近日,来自美国内华达大学Gary Kleiger和德国马普所Brenda A. Schulman研究团队在Molecular Cell上发表题为Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting的文章,发现泛素携带酶(UCE)促进的催化可能也参与底物选择,UBE2R2 E2s倾向于靶向基于CUL2的CRL2底物,细胞中CRL2依赖的PR...
The Cullin-RING ubiquitin ligases (CRLs) make nearly half of all E3s and are major mediators of proteome homeostasis. CRLs are activated by neddylation, a ubiquitin-like modification that is removed by the deneddylase COP9 signalosome (CSN). Here, based on X-ray crystallography and cryoelectron...
Cullin-RING ubiquitin ligases (CRLs) comprise the largest known category of ubiquitin ligases. CRLs regulate an extensive number of dynamic cellular processes, including multiple aspects of the cell cycle, transcription, signal transduction, and development. CRLs are multisubunit complexes composed of a ...
E3泛素连接酶参与真核生物的多种生物学过程,许多E3泛素连接酶的活性可以用催化半胱氨酸反应的探针来检测,然而像cullin-RING泛素连接酶(cullin-RING ubiquitin ligases, CRLs)家族缺乏活性位点,而是连接底物和泛素携带酶。 CRLs是一个蛋...
The COP9 signalosome (CSN) is known to bind cullin-RING ubiquitin ligases (CRLs) and to promote their activity in vivo1,2,3. The mechanism of this stimulation has remained enigmatic because CSN's intrinsic and associated enzymatic activities paradoxicall
CuLlin参与泛素复合体(Ubiquitin Complex)的组成,为泛素连接酶(Ubiquitin Ligases E3)提供疏水蛋白骨架,几乎存在于所有真核生物。CuLlin与环蛋白(RING Proteins)形成枯环泛素连接酶复合体(CuLlin-RING Ubiquitin Ligases,CRLs),与泛素等在蛋白质的定位、代谢、功能、调节和降解中都起着十分重要的作用。参与细胞周期、增殖...
Cullin-RING ubiquitin ligases (CRLs) represent the largest family of E3 ubiquitin ligases that control most if not all cellular processes. In CUL3-based CRLs, the substrate specificity is conferred by the interaction with one of around 183 existing BTB proteins, implying a broad spectrum of ...
The last decade has revealed new roles for Cullin-RING ubiquitin ligases (CRLs) in a myriad of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF (SKP1-Cullin 1-F box protein), which has been known for decades as an
Cullin 2的基因位于人类10号染色体(10p11.21),分子量约87Kd,等电点6.46。Cullin参与泛素复合体(Ubiquitin Complex)的组成,为泛素连接酶(Ubiquitin Ligases E3)提供疏水蛋白骨架,几乎存在于所有真核生物。Cullin与环蛋白(RING Proteins)形成枯灵素环泛素连接酶复合体(Cullin-RING Ubiquitin Ligases,CRLs),与泛素等在...