uitinligaseactivity,andmediatescellcycleproteins,especiallycancer associatedproteindegradationprocess,antheneffectivelyregulatesthecellcycleprogression.Cullin1playanimportantroleinthegenesisanddevel opmentofmalignanttumors.【Keywords】 Neoplasms;Cullin1 恶性肿瘤的发生发展是几个连续的步骤,包括增殖、侵袭癌旁组织、肿瘤...
Cullins are post-translationally modified by the covalent attachment of the ubiquitin-like protein Nedd8 to a conserved lysine residue in a process termed neddylation [69]. Nedd8 conjugation increases CRL ubiquitin ligase activityin vitro[52,70–72] by promoting the recruitment of the E2 through ...
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The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation Mol. Cell. Proteomics, 10 (2011) (M110 006460) Google Scholar [9] T. Bashir, N.V. Dorrello, V. Amador, D. Guardavaccaro, M. Pagano Control of the SCF(Skp2–Cks1) ubiquitin ...
2020年2月11日,南方科技大学生物系饶枫课题组和前南科大汪涛课题组合作在美国科学院院刊PNAS在线发表题为“Basis for metabolite-dependent Cullin RING ligase deneddylation by the COP9 Signalosome”的研究论文。 论文截图 通过综合性运用生物化学、结构生物学、化学生物学及遗传学等研究手段,揭示了代谢小分子六磷酸肌...
The protein was subsequently identified as Cul7 from large-scale immunoprecipitations of LT1–135 from mouse NIH3T3 cells coupled with mass spectrometry (Ali et al., 2004). Cul7 is a member of an SCF (skp1, cullin, F-box) type E3 ubiquitin ligase complex that targets cellular proteins ...
The ubiquitin ligase (E3) toward p27kip1 is thought to be SCFskp2. The activity of SCFskp2 was increased by the addition of Roc1 protein to the complex. Furthermore, the ubiquitination of p27kip1 seemed to be dependent on the phosphorylation of T187 of p27kip1 because the mutant T...
关键词: Molecular biology Functional analysis of cullin-based ubiquitin ligase and a novel UBC domain-containing protein HARVARD UNIVERSITY Xu Lai 年份: 2008 收藏 引用 批量引用 报错 分享 全部来源 求助全文 ProQuest 相似文献 参考文献Functional analysis of cullin-based ubiquitin ligase and a novel UB...
The COP9 signalosome (CSN) is known to bind cullin-RING ubiquitin ligases (CRLs) and to promote their activity in vivo1,2,3. The mechanism of this stimulation has remained enigmatic because CSN's intrinsic and associated enzymatic activities paradoxicall
两大泛素化E3连接酶家族 ——Cullins及RING家族的进化关系和适应意义 “国家大学生创新性实验计划”项目 结题报告 两大泛素化E3连接酶家族——Cullins 及RING家族的进化关系和适应意义 杨燕雯 蒋春平 指导老师:杨继 2008年3月 1