其中,E3泛素连接酶决定底物特异性。最大类的E3是CRL泛素连接酶(Cullin RING E3 Ligases)。CRL介导了总泛素化的 20%,其家族成员在多种癌症中高表达或活性上调,参与了细胞周期、生长、代谢、存活、自噬、迁移和免疫逃逸等过程相关蛋白的异常降解,是潜在的肿瘤治疗重要靶点。 2020年2月11日,南方科技大学生物系饶枫课...
Cullin-RING ligaseNEDD8NeddylationProtein-protein interactionViral hijackingUbiquitination is a highly conserved post-translational modification in eukaryotes, well known for targeting proteins for degradation by the 26S proteasome. Proteins destined for proteasomal degradation are selected by E3 ubiquitin ...
E3 ubiquitin ligase proteostasis cardiomyopathy cardiac metabolism skeletal muscle Cullin-3 muscle damage myopathy protein degradation Sorry, something went wrong. Please try again and make sure cookies are enabledCited by (25) A kelch motif-containing protein KLHDC2 regulates immune responses against Vibr...
E2 with activated ubiquitin prior to binding. Middle panels, E2 with activated ubiquitin loaded onto E3 but prior to transfer of ubiquitin to substrate. Bottom panels, the substrate has a
(2) Soares, P.; Gadd, M. S.; Frost, J.; Galdeano, C.; Ellis, L.;Epemolu, O.; Rocha, S.; Read, K. D.; Ciulli, A. Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel−Lindau (VHL) E3 Ubiquitin Ligase: Structure−Activity Relationships Leading to...
两大泛素化E3连接酶家族 ——Cullins及RING家族的进化关系和适应意义 “国家大学生创新性实验计划”项目 结题报告 两大泛素化E3连接酶家族——Cullins 及RING家族的进化关系和适应意义 杨燕雯 蒋春平 指导老师:杨继 2008年3月 1
两大泛素化E3连接酶家族 ——Cullins及RING家族的进化关系和适应意义 “国家大学生创新性实验计划”项目 结题报告 两大泛素化E3连接酶家族——Cullins 及RING家族的进化关系和适应意义 杨燕雯 蒋春平 指导老师:杨继 2008年3月 1
Schwechheimer, C. et al. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response.Science292, 1379–1382 (2001). ArticleCASGoogle Scholar Zhou, C. et al. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned...
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex Mol. Cell, 10 (2002), pp. 1519-1526 Google Scholar Zhou et al., 2013 W. Zhou, W. Wei, Y. Sun Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF)...
SCF(SKP1,Cullins,and F-box proteins)E3 ligase,also known as CRL1(Cullin-RING ligase-1)as the founding member of CRLs,is the largest family of E3 ubiquitin ligases,consisting of four components:1)an adaptor protein SKP1,2)a scaffold protein cullin-1(CUL1),3)a substrate-recognizing F-box...