其中,E3泛素连接酶决定底物特异性。最大类的E3是CRL泛素连接酶(Cullin RING E3 Ligases)。CRL介导了总泛素化的 20%,其家族成员在多种癌症中高表达或活性上调,参与了细胞周期、生长、代谢、存活、自噬、迁移和免疫逃逸等过程相关蛋白的异常降解,是潜在的肿瘤治疗重要靶点。 2020年2月11日,南方科技大学生物系饶枫课...
but the underlying mechanisms remain understudied. Here using mouse models we find that Cullin5 (CUL5), a key component of Cullin-RING E3 ubiquitin ligase 5, is upregulated and associated with increased neutrophil count
Cullin-RING E3 ubiquitin ligases (CRLs) are the largest superfamily of E3 ubiquitin ligases, with over 400 members known in mammals. These modular complexes are tightly regulated in the cell. In this chapter, we highlight recent structural and biochemical advances shedding light on the assembly ...
Kelch-like proteins, substrate adapters for the Cullin-3 (Cul3)-RING ligase (CRL3) complex, are emerging as critical regulators of striated muscle development and function, highlighting the importance of Cul3-mediated proteostasis in muscle function. To explore the role of Cul3-mediated ...
VHL蛋白是Cullin RING E3连接酶的关键底物受体蛋白。它具有广泛的组织表达,并通过识别羟基化HIF-1α转录因子,充当缺氧应激反应的关键调节因子。 在常氧(高氧)条件下,HIF-1α在特定脯氨酸残基处被脯氨酰羟化酶 (PHD) 羟基化。这些羟脯氨酸标记可被 VHL 有效识别,VHL是E3连接酶CRL2的底物受体。一旦HIF-1α被...
Cullin-RING ubiquitin ligases (CRLs) comprise the largest known category of ubiquitin ligases. CRLs regulate an extensive number of dynamic cellular processes, including multiple aspects of the cell cycle, transcription, signal transduction, and developm
两大泛素化E3连接酶家族 ——Cullins及RING家族的进化关系和适应意义 “国家大学生创新性实验计划”项目 结题报告 两大泛素化E3连接酶家族——Cullins 及RING家族的进化关系和适应意义 杨燕雯 蒋春平 指导老师:杨继 2008年3月 1
E3泛素连接酶(E3uibiquitinligases)是泛素-蛋白酶体系统中最大的一个家族体系。到目前为止被发现的泛素连接酶已有500多种,它主要划分为两大亚家族:第一类是拥有HECT结构域的E3泛素连接酶;另一类则是含有RING结构域的E3泛素连接酶[4,5],由于它们都具有保守的CUL同源结构域,因此又被称为Cullin-RingE3泛素连接酶(...
两大泛素化E3连接酶家族 ——Cullins及RING家族的进化关系和适应意义 “国家大学生创新性实验计划”项目 结题报告 两大泛素化E3连接酶家族——Cullins 及RING家族的进化关系和适应意义 杨燕雯 蒋春平 指导老师:杨继 2008年3月 1
The COP9 signalosome (CSN) is known to bind cullin-RING ubiquitin ligases (CRLs) and to promote their activity in vivo1,2,3. The mechanism of this stimulation has remained enigmatic because CSN's intrinsic and associated enzymatic activities paradoxicall