Cullin1在恶性肿瘤的发生发展中起到很重要的作用。 【关键词】 肿瘤;Cullin1Cullin1andmalignanttumors WANGWei min,DENGJian liang,ZHOUYan.DepartmentofMedicalOn cology,YixingHospital,JiangsuUniversity,Yixing214200,ChinaCorrespondingauthor:ZHOUYan,E mail:staff260@yxph.com【Abstract】 Cullin1isamemberofthecullin...
Cullin1在恶性肿瘤的发生发展中起到很重要的作用。 【关键词】 肿瘤;Cullin1Cullin1andmalignanttumors WANGWei min,DENGJian liang,ZHOUYan.DepartmentofMedicalOn cology,YixingHospital,JiangsuUniversity,Yixing214200,ChinaCorrespondingauthor:ZHOUYan,E mail:staff260@yxph.com【Abstract】 Cullin1isamemberofthecullin...
Skp1-Cullin1-F-box complexubiquitin-proteasome systemActivation of the NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known as NLRP3) inflammasome plays a key role in host immune response, which is the first line of defense against cellular stresses and pathogen ...
Protein degradation is critical for the regulation of a large number of diverse cellular processes. The majority of protein degradation in cells occurs via the ubiquitin-mediated proteolytic pathway [1,2]. Ubiquitin is an evolutionarily conserved 76 amino acid polypeptide that is covalently attached to...
It is reported that CUL1 and BRCA1 ubiquitin ligases localize on centrosome region and regulate the centrosome duplication cycle for genomic stability. In the current study, we predicted the possible interaction of E3 ubiquitin ligase CUL4A complex with γ-tubulin, a centrosome-specific protein, ...
The role of the WAVE2 complex, which consists of the 3 previously mentioned genes as well as BRICK1 and WASF2, in cardiogenesis is mostly unknown. Show abstract Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease 2019, Trends in Molecular Medicine Citation Excerpt : ...
This thesis is composed of two major areas of study: the first study describes yeast two hybrid screen and biochemical approaches which were performed to identify interaction partners for CUL-3; the second study focuses on the functional analysis of a novel ubiquitin conjugating (UBC) domain-contai...
Cullin-based E3 ligases target substrates for ubiquitin-dependent degradation by the 26S proteasome. The SCF (Skp1-Cul1F-box) and ECS (ElonginC-Cul2-SOCS box) complexes are so far the best-characterized cullin-based ligases. Their atomic... L Pintard 被引量: 394发表: 2004年 Involvement ...
Gastric cancer is a common and highly lethal malignancy in the world, but its pathogenesis remains elusive. In this study, we focus on the biological functions of CDK-associated Cullin1 (CAC1), a novel gene of the cullin family, in gastric cancer, which
gene. These results, together with the available functional data, suggest that three different types of ubiquitin ligase cullin-containing complexes were already present in early eukaryotic evolution: 1) SCF-like complexes with Cul?? proteins; 2) Cul??/BTB complexes; and, 3) Complexes containing ...