Skp1-Cullin1-F-box complexubiquitin-proteasome systemActivation of the NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known as NLRP3) inflammasome plays a key role in host immune response, which is the first line of defense against cellular stresses and pathogen ...
2013. CAND1 controls in vivo dynamics of the cullin 1- RING ubiquitin ligase repertoire. Nature Communications 4:1642. doi: 10.1038/ncomms2636, PMID: 23535663Wu S, et al. CAND1 controls in vivo dynamics of the cullin 1–RING ubiquitin ligase repertoire. Nature Commun. 2013; 4 :1642....
属第一医院口腔科主任、口腔教研室主任，学科带头人，预防保健体检中心主任。 长期从事口腔医学专业实践，在颅颌面部重点对疑难重症的综合诊治领域开展了多项 技术创新与探索。对头颈颌面部重症疑难病症的诊治实践积累了丰富的临床经验和娴熟的 诊疗操作技术，尤其擅长口腔颌面部较大组织缺损的修复重建和颌面-颅底及颌...
The ubiquitin-like protein RUB1 is conjugated to target proteins by a mechanism similar to that of ubiquitin conjugation. Genetic studies in Arabidopsis thaliana have implicated the RUB-conjugation pathway in auxin response. The first step in the pathway is RUB activation by a bipartite enzyme compo...
Function and regulation of cullin-ring ubiquitin ligases[J]. Nat Rev Mol Cell Biol, 2005,6(1):9-20. [6] Do S I, Kim K, Lee H, et al. Aberrant expression pattern and location of Cullin-1 are associated with the development of papillary carcinoma in thyroid and Cyclin D1 expression[...
Cullins Getting Undressed by the Protein Exchange Factor Cand1 Cullin-RING ubiquitin ligase complexes (CRLs) rely on a vast array of adaptor proteins to recognize their substrates. Pierce et al. and related papers from... Olma, MichaelH,I Dikic - 《Cell》 被引量: 7发表: 2013年 Ubiquitin ...
allows cullins to interact with other CRLs when released from CAND1. Neddylation is believed to induce conformational changes in CRLs (blue arrow), which leads to their interaction with the E2-ubiquitin complex and substrate ubiquitination. Ubiquitination often leads to proteolytic degradation or substr...
[2]Bosu DR,Kipreos ET.Cullin-RING ubiquitin ligases:global regulation and activation cycles[J].Cell Div,2008,3:7. [3]Angers S,Li T,Yi X,et al.Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery [J].Nature,2006,443(7111):590-593. [4]Kanarek N,Horwitz E...
BTB-Kelch proteins are substrate-specific adaptors for cullin-3 (Cul3) RING-box–based E3 ubiquitin ligases, mediating protein ubiquitylation for subsequent proteasomal degradation. Vaccinia virus encodes three BTB-Kelch proteins: A55, C2, and F3. Viruses lacking A55 or C2 have altered cytopathic ef...
Dysfunction of E3 ubiquitin ligases contributes to abnormal cell growth and differentiation [6]. As the biggest family of E3 ubiquitin ligases, the Skp1/Cullin/Rbx1/F-box protein (SCF) complexes ubiquitinate a broad range of proteins involved in cell-cycle progression, signal transduction and ...