The ubiquitin鈥損roteasome system is responsible for site- and target-specific ubiquitination and protein degradation. Specificity of ubiquitination is conferred by ubiquitin ligases. Cullin-RING complexes, the largest family of ligases, require multi-unit assembly around one of seven cullin proteins. ...
J. Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol. Cell Biol. 6, 9–20 (2005). Article CAS PubMed Google Scholar Fang, S., Lorick, K. L., Jensen, J. P. & Weissman, A. M. RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and ...
CRLs are a family of multi-unit E3 ubiquitin ligases complex, consisting of 4 subunits: a scaffold cullin with 8 family members, an adaptor with many members, a substrate receptor with hundreds of members, and a RING component with two family members, RING-box 1 (Rbx1/Roc1) and RING-box...
The Role of Ubiquitin-Protein Ligases in Neurodegenerative DiseaseThe Role of Ubiquitin-Protein Ligases in Neurodegenerative DiseaseUbiquitylationUbiquitin-protein ligaseSkp1-Cdc53/cullin-F-box complexesRING domainHECT domainNeurodegenerationInclusionsAggresomesAlzheimer...
MLN4924 is a small molecule inhibitor of NEDD8-associated NAE enzyme activity that blocks neddylation-dependent cullin-RING ubiquitin ligases to induce tumor cell apoptosis [6]. MLN4926 is currently being clinically evaluated. Efforts are underway to target ubiquitin-conjugating enzymes, as exemplified ...
The cullin-RING ubiquitin-protein ligases 2011, Annual Review of Plant Biology ERAD: The long road to destruction 2005, Nature Cell Biology Endoplasmic reticulum-associated degradation 2005, Annual Review of Cell and Developmental Biology The SCF ubiquitin ligase: Insights into a molecular machine 2004...
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The present findings indicate that cGMP increases NKCC2 ubiquitination via a cullin-RING ligase complex and regulates in part surface NKCC2 levels. Identifying the E3 ubiquitin ligases that regulate NKCC2 expression and activity may provide new targets for the development of specific loop diuretics....
Tandem repeats of a degenerate 34-amino-acid sequence that mediate protein–protein interactions. HECT domain (Homologous to E6-AP C terminus domain). HECT- and RING-domain-containing proteins are the two main classes of E3 ubiquitin ligases. In contrast to RING ligases, HECT-domain ligases form...
The cell cycle is tightly regulated by protein phosphorylation and ubiquitylation events. During mitosis, the multi-subunit cullin-RING E3 ubiquitin ligase APC/c functions as a molecular switch which signals for one cell to divide into two daughter cells