J. Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol. Cell Biol. 6, 9–20 (2005). Article CAS PubMed Google Scholar Fang, S., Lorick, K. L., Jensen, J. P. & Weissman, A. M. RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and ...
The APC is an approximately 1 MDa, tightly associated complex of 11 to 13 subunits that are generally well conserved in eukaryotes (Figure4; Table1). The APC is a cullin-RING-type ubiquitin-protein ligase [7], in which the Apc2 and Apc11 subunits contain the cullin and RING domains, re...
It acts as a bridge between the enzymatic complex of the SCF (skp1, cullin, F-box protein) and the substrate. Peptides correspond to the digested substrates. Table 1. Muscle-specific E3 ubiquitin ligases E3 ubiquitin ligaseTypeSubstrateReferences Atrogin-1 (MAFbx) RING finger, SCF complex CnA...
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications . Embo J . 2013. Aug 28; 32 ( 17 ):2307–20. PMCID: 3770339. Epub 2013/08/06. eng. doi: 10.1038/emboj.2013.173Genschik P, Sumara I, Lechner E. The emerging family of CULLIN3...
Here, we show that DDB2 and CSA both link to a cullin-based ubiquitin ligase and that regulation of the ligase activity by CSN plays a crucial role in NER. Cullin-based ubiquitin ligases consist of cullin, a RING finger protein, adaptors, and a substrate recognition protein. The well-charac...
[41,42]. Mechanistically, this happens through the recruitment of the cullin RING ubiquitin ligases by the essential viral early protein Gam1 and the formation of a complex with SAE1/2 [42]. The cullin RING ubiquitin ligases ubiquitinate SAE1, resulting in the degradation of SAE1 by the ...
Cullin-RING E3 ubiquitin ligase (CRL) complexes, the largest family of E3 ligases with more than 200 members. Although CUL7 and PARC are present only in chordates, other members of the cullin protein family are found inDrosophila melanogaster,Caenorhabditis elegans, Arabidopsis thalianaand yeast. ...
Cullin proteins, adaptor proteins, substrate receptor proteins, and Ring-finger proteins.3,4Among them, Cul3-RING ligases (CRL3s) are well studied E3 ubiquitin ligases consisting of Cul3 as the scaffold in complex with Ring-finger protein RING-box protein 1 (ROC1) at the C-terminus of Cul...
Key mediators of signaling pathways in breast cancer involve post-translational protein modification, primarily mediated through phosphorylation and ubiquitination. While previous studies focused on phosphorylation events, more recent analysis suggests t
a, Modular structure of cullin–RING E3 ubiquitin ligases. Edge colours unite domain(s) within the same protein molecules. Shading highlights individual domains as cullins (purple), adaptor proteins (light blue), substrate-binding modules (green), or other (grey). CSN, Cop9/signalsome. b, ...