The trajectories of cell movement depend on the size, rhythm, and direction of long series of pseudopods. These pseudopod properties are regulated by internal factors such as memory of previous directions and by external factors such as gradients of chemoattractants or electric currents. Here a ...
The trajectories of cell movement depend on the size, rhythm, and direction of long series of pseudopods. These pseudopod properties are regulated by internal factors such as memory of previous directions and by external factors such as gradients of chemoattractants or electric currents. Here a ...
In spite of these dramatic changes in pseudopodium behaviour, the underlying motility cycle of both mutants remains normal. The levels of F-actin in both mutant cell lines are significantly elevated with respect to the wild-type parental cells, suggesting a possible biochemical basis for these ...
and new blebs were continuously generated (Movie S1), so kymographs fromscarknockout cells have a stepped appearance (Figure 3B). Wild-type SCAR (WT) rescues normal pseudopod progression (Figure 3A;Movie S2), giving kymographs with smooth runs interspersed with steps when the leading edge spli...
(Blaser et al. in Dev Cell 11:613–627, 2006). Cell blebbing activates phagocytes and promotes the rapid removal of intrinsic compartments. However, recent studies have revealed that blebbing is associated with dynamic cell reorganization and alters the movement of cells in-vivo and in-vitro (...
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Cells invading collectively exhibit preserved inter-cellular junctions with leader cells paving the way for the collective. In individual cell invasion, each cell invades the basement membrane via highly proteolytic mesenchymal cell movement or plasma membrane blebbing. In HNSCC, disruption of the ...
Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Curr. Biol. 22, 553–561 (2012). CAS PubMed PubMed Central Google Scholar Chen, B. et al. The WAVE regulatory complex links diverse receptors to the actin cytoskeleton. Cell 156, 195–207...
We stored the coordinates of each node and we assigned a type to each node, depending on whether the node fell inside a pseudopod, the initial cell, or the veins. After constructing the graph, a subroutine calculated the connectivity of each node, and simplified the graph in order to avoid...
Rac1 Drives Melanoblast Organization during Mouse Development by Orchestrating Pseudopod-Driven Motility and Cell-Cycle Progression Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, et al. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility ...