Active tumor cell motility has long been appreciated to play a major role in invasion and metastasis. Tumor cells exhibit an amoeboid movement similar to that of polymorphonuclear (PMN) leukocytes and the lower eukaryote Dictyostelium , characterized by pseudopod protrusion at the leading edge of ...
anionic but not cationic surfaces promoted two modes of pseudopod formation by HCS-2/8 cells, in a random progression and as a “cell recognition signal”. This phenomenon was associated with a cellular mechanism to optimize the anchoring process. Interestingly, cells developed pseudopods on cation...
The process during embryogenesis whereby the embryo is transformed from a hollow sphere of cells into a structure with three germ layers: ectoderm, mesoderm and endoderm. Lamella The flattened region immediately behind the lamellipodium. Glu-tubulin (Also known as detyrosinated tubulin). A post-...
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Many blasts exhibited cell surface irregularity characterized by pseudopod formation. Nuclear irregularity was prominent. In an initial study performed three months after culture initiation, a subpopulation (about 30%) of large and small blasts was detected that contained large granules resembling immature...
To assess the potential impact of CR cell death in the development of the cortical circuit, we first aimed to identify the circuit that CRs are part of. To achieve this in a comprehensive and unbiased manner, we utilized compound mouse genetics in combination with pseudo-typed rabies viral tra...
MDA-MB-231 human breast cancer cells were used to study attachment and detachment during the cell cycle as well as explore the influences of the chemokine SDF-1 (enabling the quantification of the role of chemokine gradients both on pseudopod formation and directional cell migration). 展开 ...
These microdomains are enriched with the transmembrane protein p80, and thus p80 at the plasma membrane can be used to monitor exocytosis in D. discoideum (Charette and Cosson, 2006). To determine whether polyP causes the retention of TRITC–dextran by inhibiting exocytosis, we examined total...
Understanding sulcozoan evolution clarifies the origins from them of opisthokonts (animals, fungi, Choanozoa) and Amoebozoa, and their evolutionary novelties; Sulcozoa and their descendants (collectively called podiates) arguably arose from Loukozoa by evolving posterior ciliary gliding and pseudopodia ...
G. Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin–protein interactions? Dev. Cell 23, 11–20 (2012). CAS PubMed PubMed Central Google Scholar Byrne, D. P., Dart, C. & Rigden, D. J. Evaluating caveolin interactions: do ...