The cell type exhibiting a characteristic variable morphology, cell bodies with long protrusions and a single membrane with an elaborate surface proteome was therefore identified as ‘Ca.L. ossiferum’. These cells often appeared as individuals in FISH analyses (Extended Data Fig.7a) and electron ...
Dashed arrow indicates that alteration of proteins associated with the cytoskeleton in the TIF might reduce endocytosis, exocytosis, membrane recycling or membrane fluidity. The proposed pathway diagram was created using BioRender.com. Physical properties of cell membranes, such as membrane fluidity,...
Previous studies have reported that exosomes are likely secreted from the uropod or tail of migrating cells46,47; however, those studies were performed with Dictyostelia and leukocytes that primarily use amoeboid locomotion for movement, involving the formation of posterior uropods. By contrast, mesen...
In the first step of migration, the lamellar pseudopods of the cells need to form adhesion to the substrate in order to have a point of support to pull the cells [30]. Therefore, Western blot and immunofluorescence techniques were used here to detect paxillin, a marker of FA, in order ...
The interaction of Yersinia with host surface integrins induces activation of the cytoskeleton and the rearrangement of actin into pseudopods that engulf the bacteria (Krukonis and Isberg, 1997). A number of microbial pathogens, including B. pertussis, Coxiella burnetti, E. coli, Histoplasma capsula...
System of protein filaments crisscrossing the inner part of the cell and which, with the help of the many proteins that interact with it, enables the cell to insure its structural integrity and morphology, exert forces and produce motion. ...
The contributions of the whole trajectory can eventually comprise a quantitative signature in which correlated events appear more or less frequently than would be expected by chance (shown below the main diagram, with blue indicating a higher (and red a lower) likelihood. The calculation of the ...
Fig. 4: Cellular decrease of expressed ORs with higher differentiation status. aMonocle-generated pseudotemporal trajectory of malignant breast epithelial cells of luminal A molecular subtype of breast carcinoma, depicting the decrease in cellular stemness during cellular differentiation time-course (pseudot...
nucleus and promote liver cancer cell growth by interacting with WDR5 protein through their NTEs [15]. PTENε, a smaller PTEN variant primarily located in the cell plasma membrane, inhibits the formation of pseudopods and reduces the migratory ability of tumor cells, thereby repressing cancer ...
The other similarity among these experiments is the actual adhesion process once the cells are in contact with a surface. Once the cells settle to the surface, the platelets, as well as the EC, then initiate adhesion by extending pseudopods. The central portion of the cell then follows these...