These pseudopod properties are regulated by internal factors such as memory of previous directions and by external factors such as gradients of chemoattractants or electric currents. Here a simple method is described that defines the X, Y time coordinates of a pseudopod at the start and the end...
(temporal sensing model) or it only protrudes one pseudopod in the direction of the external signal (spatial sensing model); – finally, the protrusion of the pseudopodia and the contraction of the cell body are tightly synchronized with the adhesion forces at the back and at the front, ...
The trajectories of cell movement depend on the size, rhythm, and direction of long series of pseudopods. These pseudopod properties are regulated by internal factors such as memory of previous directions and by external factors such as gradients of chemoattractants or electric currents. Here a ...
and new blebs were continuously generated (Movie S1), so kymographs fromscarknockout cells have a stepped appearance (Figure 3B). Wild-type SCAR (WT) rescues normal pseudopod progression (Figure 3A;Movie S2), giving kymographs with smooth runs interspersed with steps when the leading edge spli...
Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Curr. Biol. 22, 553–561 (2012). CAS PubMed PubMed Central Google Scholar Chen, B. et al. The WAVE regulatory complex links diverse receptors to the actin cytoskeleton. Cell 156, 195–207...
Shows that the Par polarity complex, previously known to establish apical–basal polarity, drives front–rear polarization in migrating keratinocytes; blocking Par complex function increases random migration and inhibits chemotaxis, probably by interfering with microtubule stabilization at the leading edge ...
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macropinocytosis is anin vitroactivity which simply reflects an inherent capability to generate the pseudopod extensions that engulf phagocytic ligands. There are several similarities between phagocytosis and macropinocytosis. Both are dependent on remodeling of the actin cytoskeleton and cdc42 is an importa...
As a result, p27 is destabilized in the cells with impaired Cdh1 function and the G1 phase is shortened in these cells. Our recent work identified Ets2 as a new substrate of APCCdh1 [14]. Ets2 is a member of the Ets family of transcription factors which share a unique DNA binding ...
Atrial fibrillation (AF) has high mortality and morbidity rates. However, the intracellular molecular complexity of the atrial tissue of patients with AF has not been adequately assessed. We investigated the cellular heterogeneity of human atrial tissue