Mauro Piacentini Marco Tripodi Giuseppe Ippolito ObituaryOpen Access04 Mar 2024 Cancer stem cell immunoediting by IFNγ The secretion of interferon gamma (IFNG, best known as IFNγ) by immune effector cells generally mediates potent anticancer effects. Recent data from Beziaud et al. demonstrate th...
Drug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. During the past decades, several agents have been identified with various postulated mechanisms of bile duct damage, however, mostly
A high recurrence rate and easy metastasis are two prominent clinical features of hepatocellular carcinoma (HCC), which is also the most common cause of cancer-related death. However, the molecular pathogenesis of HCC remains unclear. Soluble resistance-
Glutamine-deficient tumor cells undergo cell cycle arrest, which can be re-established by the addition of exogenous nucleotides; but, it is difficult to restore by the addition TCA intermediates [49]. During pyrimidine synthesis in tumor cells, the nitrogen required for two specific enzymatic steps...
Its pioneering CAR-T cell therapies include: anti-GPC3 CAR-T for hepatocellular carcinoma (HCC), anti-GPC3 CAR-T for squamous lung cancer (SLC), cancer-specific anti-EGFR CAR-T for glioblastoma multiforme (GBM) and first-in-class anti-Claudin18.2-CAR-T for gastric and pancreatic cancer. ...
by Miran Rada *, Migmar Tsamchoe †, Audrey Kapelanski-Lamoureux †, Nour Hassan , Jessica Bloom , Stephanie Petrillo , Diane H. Kim , Anthoula Lazaris and Peter Metrakos * Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canad...
Cancer is associated with uncontrolled cell proliferation, and the majority of drugs achieve antitumor effects by inhibiting uncontrolled cell proliferation by arresting the cell cycle of tumor cells [24]. There are four cell cycle regulatory points in the G1, S, G2, and M phases that can regu...
Estimation and prediction of cell cycle specific effects of anticancer drugs - Kimmel, Traganos - 1986 () Citation Context ...tion of these methods allow the quantification of the cell-cyclephase action of many agents. One of the interesting findings was the existence of after effects in the ...
Recently, numerous molecular targeted drugs that act specifically on a specific molecule have been developed for use as anticancer drugs. In particular, development has been proceeding on various antibody drugs having, as antigens, molecules specifically expressed in certain cancer cells or molecules exh...
We postulate that while Vitamin D3 as anticancer drug inhibits proliferation of malignant cells, it may protect normal stem cells that play an important role in development and tissue/organ regeneration.Background Germline cell tumors are derived from cells endowed with early developmental potential. ...