Modifications to bodily functions and physiology are known to occur with age. These changes can have a considerable impact on the pharmacokinetic processes of absorption, distribution, metabolism and excretion and the pharmacodynamic properties of administered drugs. For many drugs with a high therapeutic...
"Chemistry and Pharmacology of Anticancer Drugs" is a comprehensive survey of all families of anticancer agents currently in use or in advanced stages of clinical trials, including biologicals. The book is unique in providing molecular structures for all anticancer drugs, discussing them in terms of...
It is estimated that 1.2 million new cases of cancer will be diagnosed in the United States in 2000. Although treatment advances encompassing several disciplines, including surgery, radiation treatment, and medical oncology, have reduced the mortality rate from cancer by 16% between 1950 and 1995 ...
25楼:Originally posted byraphael813at 2012-11-05 14:03:58 有成功下载打开的吗?好像不行呢 可以...
DNA polymerase η (polη) is of significant value for designing new families of anticancer drugs. This protein takes a role in many stages of the cell cycle, including DNA replication, translesion DNA synthesis, and the repairing process of DNA. Accordin
Chemistry and Pharmacology of Anticancer Drugsby David E Thurston has tackled a mountain of information that exists regarding the current state of cancer chemotherapy. The sheer volume of information published on both cancer and chemotherapeutics is frequently discouraging to novice cancer researchers and...
Multidrug resistance-associated protein 1 (MRP1, ABCC1) is one of the ATP-binding cassette (ABC) pumps able to export anticancer drugs from cancer cells, conferring pharmacoresistance. More than twenty SVs of MRP1 have been described in cancer (e.g., ovarian cancer), with a higher expressio...
1 Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA. 2 Laboratory of Non-human Primate Disease Model Research, National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy, West China Hospital, Sichuan ...
The outcome of anticancer chemotherapy can depend on the tumour’sp53status (Soussi and Beroud, 2001). Tumour cells with mutated or deletedp53tend to be less responsive to several commonly used chemotherapeutic drugs, such as topoisomerase inhibitors, anthracyclines or alkylating agents (Lowe et al...
At present, the treatment mainly includes surgery and chemotherapy, but the restorative effects of the existing chemotherapeutic drugs are not good enough and they have many side effects. Therefore, development of highly efficient, selective and less noxious antitumor drug remains a hot research area....