Anti-Cancer Drugs design课件 Anti-CancerDrugs ❖2007,12million，annualdeadover7million ❖sales：(15%annual)2004,240billion2007,396billion2008,480billion2009,550billion2012,800billion ❖annualincreaserate15%，❖1997~2008，Targeted-drug:about15个！1997,Rituxan1998,Herceptin(1.6billion)Thetimeof...
抗癌药(Anti-Cancer Drugs) 北京协和医学院基础医学院 药理学系 叶菜英 Overview Introduction ? Malignant disease accounts for a high proportion of deaths in industrialised countries. ? The treatment of anticancer drug is to give palliation, induce remission and, if possible, cure. Overview ...
Procarbazine hydrochloride (MIH, Matulane) Procarbazine has the ability to alkylate through free radical formation. The compound in initially activated in vivo to active form in which methylhydrazine is formed and is farther oxidized to methyldiazine which results in the formulation of the hydrogen and...
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Anti-cancer therapy DNA alkylating agents 1. Cell cycle inhibitors Anti-cancer therapy DNA alkylating agents Cross-linking of DNA because of drug-[G] bonding Nitrogene mustards: Cyclophosphamide- side effect of hemorrhagic cystitis, reduced by Mesna Chlorambucil Nitrosourea drugs: Carmustine, Lomustine...
Anti-CancerDrugs北京协和医学院基础医学院药理学系叶菜英OverviewIntroduction Malignantdiseaseaccountsforahighproportionofdeathsinindustrialisedcountries. Thetreatmentofanticancerdrugistogivepalliation,induceremissionand,ifpossible,cure.OverviewIntroduction Canceroccursafternormalcellshavebeentransformedintoneoplasticcellsthrough...
cancer cells. In the development of such antibody drugs, a comparison is first made between expression of mRNA in cancer tissue collected at the time of surgery and expression of mRNA in normal tissue collected from a nearby site, molecules specifically expressed only in cancer tissue or ...
1. Overview: (1)Chemotherapy( 化学治疗, 简称化疗 ) (2)Chemotherapeutic drugs: Antimicrobial drugs( 抗微生物药 ); Antiparasitic durgs( 抗寄生虫药 ); Antineoplastic drugs( 抗肿瘤药 ). (3)Antimicrobial drugs: Antibacterial drugs( 抗菌药 ); Antifungal drugs( 抗真菌药 ); Antiviral drugs( 抗病毒...
Chemotherapy: A cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. hsbc.com.hk 化学治疗:使用药物杀死癌细胞或 令其 停止分裂,阻碍生长。 hsbc.com.hk Morinda citrifolia fruit juice and some cancer chemotherap...
In other MDR leukemia cells such as daunomycin or vinblastine-resistant leukemia cell models, various ginsenosides including 20(S)-PPT, Rh2 and compound K were found to greatly enhance the cytotoxicity of anti-cancer drugs in a range of 2- to 46-fold through the blockage of drug efflux [...