Cell cycle specific drugs have advantages over conventional toxic cancer drugs. Immobilization of these drugs aims at increasing their bioavailability and efficiency. DFMO (Difluoromethyl-ornithine) inhibits polyamine biosynthesis by binding to the rate limiting enzyme Ornithine decarboxcylase (ODC). ...
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Analysis of FDA approved anticancer drugs reveals the future of cancer therapy. Cell Cycle. 2004;3:1035–42. http://www.ncbi.nlm.nih.gov/pubmed/15254418 Article CAS Google Scholar Fischer I, Nickel A-C, Qin N, Taban K, Pauck D, Steiger H-J, et al. Different calculation strategies ...
Aberrant activity of cell cycle protein kinases, leading to uncontrolled cell proliferation, is a hallmark of human cancer. Here, Lapenna and Giordano review recent progress in the modulation of specific protein kinase activity for the treatment of vario
(EMA), respectively. Henlius actively promotes HANSIZHUANG in conjunction with in-house products of the company such as tumour-specific target, angiogenesis target, immunotherapeutic target, etc. and chemotherapy drugs to condu...
over other MSCs because they exhibit minimal immunogenicity and can be produced in large numbers. Following the overexpression of NLRP1 and caspase-4, hUCMSCs cause pyroptosis of the MCF-7 breast cancer cell line; however, hUCMSC treatment has little to no effect on the cell cycle [322]. ...
Efficiency Of Proteolytic Enzymes In Treating Lumbar Spine Osteoarthritis (Low Back Pain) Patients And Its Effects On Liver And Kidney Enzymes Cancer Basic Research GI and Oncologic Surgery - Unusal Presentations of Meckel`s Diverticulum New Trends of Warthin Tumor Management: A Systematic Review of ...
Cellular dormancy means that cells are recruited into the G0-phase of the cell cycle but remain capable of cell division in response to mitotic stimulation [85]. Chemotherapy and irradiation are mainly effective against proliferating cells. It is likely that dormant tumor cells comprise both CSC ...
A particular form of apoptosis that occurs during mitosis as a result of aberrant chromosome segregation or DNA damage, typically related to inactivation of cell cycle checkpoints. Synthetic lethality With regard to cancer therapy, this concept postulates that inhibition of a specific protein is lethal...
C. The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies. Nat. Immunol. 21, 835–847 (2020). Article CAS PubMed PubMed Central Google Scholar Liu, S. et al. NK cell-based cancer immunotherapy: from basic biology to clinical development. J. Hematol. ...