Testicular germ cell tumours: The paradigm of chemo-sensitive solid tumours Alessandra di Pietro, ... Steven de Jong, in The International Journal of Biochemistry & Cell Biology, 2005 The cell cycle is an ordered sequence of four phases (G1/0, S, G2, M), in which the control of the ...
Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma. J Mater Chem B. 2020;8:4648–59. Article CAS PubMed Google Scholar Spicer JD, McDonald B, Cools-Lartigue JJ, Chow SC, Giannias B, Kubes P, et al. ...
By combining living cells with therapeutics, cell–drug conjugates can potentiate the functions of both components, particularly for applications in drug delivery and therapy. The conjugates can be designed to persist in the bloodstream, undergo chemotax
MK-8776 (Scheme 900776)Targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activitiesTreatment of neoplasms, hodgkin disease, adult erythroleukemia, lymphoma, non-hodgkin, and myelogenous leukemia, acute, among othersPhase I/NCT00779584Labroli et al. ...
A pharmacodynamic model is proposed and equations are developed for the quantitative analysis of dose-time-cell-survival curves produced by the administration of cell-cycle-specific chemo-therapeutic agents. The essential feature of the model is an irreversible, bimolecular mechanism of drug-receptor ...
Detecting radio- and chemoresistant cells in 3D cancer co-cultures using chromatin biomarkers Article Open access 24 November 2023 Main Small molecules play a role in regulating cellular processes, and impacting gene expression, chromatin structure and signaling pathways. These interactions serve as the...
Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements. J Exp Clin Cancer Res CR. 2015;34(1):81. Article PubMed Google Scholar Tavakolian S, Goudarzi H, Kazeminezhad B, Faghihloo E. Prevalence of herpes simplex...
Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in our knowledge of the causes for MCL and availa
Taxanes, microtubules and chemoresistant breast cancer Journal 2008,Biochimica et Biophysica Acta (BBA) - Reviews on Cancer Barbara T.McGrogan, ...AmandaMcCann Antimitotic drugs bind to different sites on the tubulin heterodimers (a) Vincristine binds to the vinca domain at the microtubule plus (...
Chemical inhibition has emerged as a powerful approach to advance our understanding of these mitotic kinases, and numerous inhibitors are being developed as potential anticancer drugs. Other cell cycle regulators, such as the DNA damage checkpoint kinases and spindle-assembly checkpoint proteins, are ...