Chemotherapy is one of the pillars of cancer treatment, with first reports of its use dating back hundreds of years. Cytotoxic drugs damage malignant cells through various mechanisms, leading to creation of several pharmacologic classes. In this chapter, we first describe the cell cycle and how a...
(1999) Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood 93: 3678–3684 CAS PubMed Google Scholar Nabhan C et al. (2004) Gemtuzumab ozogamicin (MylotargTM) is infrequently associated with ...
Furthermore, while integrating IL-2 into the chemotherapy regimen interfered with the hierarchy of the response, IL-2 or other strategies that support CTL activity could be considered upon completion of chemotherapy. 展开 关键词: Chemotherapy Cytotoxic T lymphocyte Tumor antigen Epitope spreading ...
X Wu, “Cytotoxic Activity of Schisandrolic and Isoschisandrolic Acids Involves Induction of Apoptosis”, Chemotherapy (Basel, Switzerland), 2007, 53, 257-262. :Tian Z, Xu L, Zhou L, Yang M, Chen S, Xiao P, Wu E. Cytotoxic activity of schisandrolic and isoschisandrolic acids ...
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cell(redirected from cytotoxic cell)Also found in: Dictionary, Thesaurus, Medical, Legal, Encyclopedia. Related to cytotoxic cell: CD8+ cellcell an independent team of operatives who work together in a CELLULAR MANUFACTURING production environment. Collins Dictionary of Business, 3rd ed. © 2002, ...
Non-small-cell lung cancer and breast carcinoma: chemotherapy and beyond Early screening, adjuvant and sequential systemic treatment, and hormonal therapy have benefits in treatment of breast cancer. Management of non-small-cell... S Dubey,JM Siegfried,AM Traynor - 《Lancet Oncology》 被引量: 138...
Cancer cell resistance to chemotherapy is often mediated by overexpression of P-glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter whic... AD Pietro,G Conseil,JM Pérez-Victoria,... - 《Cellular & Molecular Life Sciences》 被引量: 384发表: 2002年 Inositol hexakisphosphate bloc...
Cancer, one of the principal causes of death, is a multifactorial disease that comprises numerous genetic defects and is characterized by abnormal growth of cells1,2. According to the World Health Organization (WHO) nearly 10 million cancer deaths occurred in 2022 in worldwide. Chemotherapy is co...
44,45 In addition, the combination of pembrolizumab with cytotoxic chemotherapy demonstrated clinical benefit, and was approved by the US Food and Drug Administration (FDA) for first-line treatment of metastatic non-small-cell lung cancer (NSCLC).46 The FDA has also approved pembrolizumab or av...